3,3-二甲基-1,2,3,4-四氢异喹啉合成路线 （共 8 条）
反应条件
1: naphthalene With Sodium hydride in formaldehyde diethyl acetal 4 h; 2: 3,3-dimethyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline in formaldehyde diethyl acetal 2 h;
参考文献
Aventis Pharmaceuticals Inc.
Patent: EP929527 B1, 2004 ;
Location in patent: Page 5 ;
反应条件
1: 99 percent / boron trifluoride diethyl etherate / 12 h / Ambient temperature 2: 86 percent / naphthalene, sodium / various solvent(s) View Scheme
参考文献
Demory, Emilien; Farran, Daniel; Chavant, Pierre Y.; Blandin, Veronique; Baptiste, Benoit
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 7901 - 7912,12
反应条件
naphthalene; sodium in various solvent(s)
参考文献
Watson
Journal of Organic Chemistry, 1998 , vol. 63, # 2 p. 406 - 407
反应条件
1: 99 percent / triethylamine / CH2Cl2 / 12 h / Ambient temperature 2: 99 percent / boron trifluoride diethyl etherate / 12 h / Ambient temperature 3: 86 percent / naphthalene, sodium / various solvent(s) View Scheme
参考文献
Watson
Journal of Organic Chemistry, 1998 , vol. 63, # 2 p. 406 - 407
反应条件
ammonia; lithium; toluene-4-sulfonamide T=-50 - -33°C; Inert atmosphere;
参考文献
Demory, Emilien; Farran, Daniel; Chavant, Pierre Y.; Blandin, Veronique; Baptiste, Benoit
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 7901 - 7912,12
反应条件
1: triethylamine / dichloromethane / 20 °C / |Inert atmosphere 2: boron trifluoride diethyl etherate / |Inert atmosphere 3: toluene-4-sulfonamide; ammonia; lithium / -50 - -33 °C / |Inert atmosphere View Scheme
参考文献
Demory, Emilien; Farran, Daniel; Chavant, Pierre Y.; Blandin, Veronique; Baptiste, Benoit
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 7901 - 7912,12
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Heating;
参考文献
Mikhailovskii, A. G.; Aleksandrov, B. B.; Vakhrin, M. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1993 , vol. 29, # 6 p. 668 - 670
Khimiya Geterotsiklicheskikh Soedinenii, 1993 , # 6 p. 780 - 783
反应条件
sodium tungstate; dihydrogen peroxide in methanol; water Inert atmosphere;
参考文献
Demory, Emilien; Farran, Daniel; Chavant, Pierre Y.; Blandin, Veronique; Baptiste, Benoit
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 7901 - 7912,12
