2-羟基-5-硝基-6-甲基吡啶合成路线 （共 22 条）
反应条件
sulfuric acid; water; sodium nitrite T=0 - 10°C; 1 h;
参考文献
KARO BIO AB; ELSY, David
Patent: WO2005/42464 A1, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/042464 A1
反应条件
hydrogenchloride; water Reflux;
参考文献
Hartz, Richard A.; Ahuja, Vijay T.; Schmitz, William D.; Molski, Thaddeus F.; Mattson, Gail K.; Lodge, Nicholas J.; Bronson, Joanne J.; Macor, John E.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1890 - 1894
反应条件
sulfuric acid in water
参考文献
Bristol-Myers Squibb Company
Patent: US6011029 A1, 2000 ;
反应条件
1: concentrated H2SO4; concentrated HNO3 2: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization View Scheme
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
1: liquid NH3; xylene; Fe(NO3)3 2: concentrated H2SO4; concentrated HNO3 3: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
参考文献
Baumgarten et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 596,598
反应条件
hydrogenchloride; sodium nitrite Diazotization;
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
1: phosphorus (V)-chloride; phosphoryl chloride 2: sodium acetate; ethanol; N2H4+H2O View Scheme
参考文献
Baumgarten; Su
Journal of the American Chemical Society, 1952 , vol. 74, p. 3828,3830
反应条件
1: phosphorus pentachloride; trichlorophosphate 2: palladium on carbon; hydrogen 3: tetrafluoroboric acid; EtO-NO 4: iodine; potassium acetate / acetic anhydride 5: ozone View Scheme
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
1: 6-methyl-5-nitropyridin-2-ol With phosphorus oxytribromide in tetrachloroethane, 1,1,2,2- 4 h; Heating / reflux; 2: zinc cyanide With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; 5 h;
参考文献
Melton, Laura J.
Patent: US2005/281746 A1, 2005 ;
Location in patent: Page/Page column 15-16 ;
