反应条件
1: NaN3; NH4Cl / aq. ethanol / 18 h / Heating 2: pyridine; DMAP / 16 h / 20 °C 3: lipase Amano-PS; aq. phosphate buffer / 2.5 h / pH 7.2 4: MeONa / methanol 5: H2 / PtO2 / ethyl acetate / 20 °C / 1810.02 - 2068.59 Torr 6: 97.9 percent / pyridine; DMAP / 0 °C 7: NaN3 / dimethylformamide / 65 - 70 °C 8: H2 / PtO2 / methanol / 3 h / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Nagata, Tsutomu; Yoshino, Toshiharu; Haginoya, Noriyasu; Yoshikawa, Kenji; Isobe, Yumiko; Furugohri, Taketoshi; Kanno, Hideyuki
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4683 - 4688