3-溴-5-(3-甲基噻吩-2-基)吡啶合成路线 (共 3 条)
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane Suzuki coupling; Heating;
参考文献
Fraley, Mark E.; Arrington, Kenneth L.; Hambaugh, Scott R.; Hoffman, William F.; Cunningham, April M.; Young, Mary Beth; Hungate, Randall W.; Tebben, Andrew J.; Rutledge, Ruth Z.; Kendall, Richard L.; Huckle, William R.; McFall, Rosemary C.; Coll, Kathleen E.; Thomas, Kenneth A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 18 p. 2973 - 2976
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane; water T=80°C; Suzuki-Miyaura coupling; 24 h; Reflux;
参考文献
De Giorgi, Marcella; Voisin-Chiret, Anne Sophie; Sopkova-De Oliveira Santos, Jana; Corbo, Filomena; Franchini, Carlo; Rault, Sylvain
Tetrahedron, 2011 , vol. 67, # 34 p. 6145 - 6154
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in cyclohexane; water; ethyl acetate; toluene
参考文献
Miller, Craig Harrison; Dull, Gary Maurice; Miao, Lan; Lynm, Dwo; Schmitt, Jeffrey Daniel; Clark, Thomas Jeffrey
Patent: US2002/13309 A1, 2002 ;
Title/Abstract Full Text Show Details
Targacept, Inc.
Patent: US6852721 B2, 2005 ;