2-(乙酰氧基)苯甲酸3-(羟基甲基)苯基酯合成路线 （共 6 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran; methanol T=0°C; 0.333333 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water
参考文献
PIRAMAL LIFE SCIENCES LIMITED
Patent: US2011/263526 A1, 2011 ;
Location in patent: Page/Page column 82 ;
反应条件
potassium carbonate in acetone T=5 - 10°C; 2 h;
参考文献
Nicox S.A.
Patent: US6696591 B1, 2004 ;
Location in patent: Page column 4 ;
反应条件
1: Et3N / CH2Cl2 / 0 °C 2: NaBH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED
Patent: US2011/263526 A1, 2011 ;
反应条件
1: SOCl2; pyridine / CH2Cl2 / 2 h / 0 °C 2: Et3N / CH2Cl2 / 0 °C 3: NaBH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
Chiroli, Valerio; Benedini, Francesca; Ongini, Ennio; Del Soldato, Piero
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 441 - 446
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C 2: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.33 h / 0 °C View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED
Patent: US2011/263526 A1, 2011 ;
反应条件
nitric acid; acetic anhydride in dichloromethane T=0 - 20°C; 2 h;
参考文献
Nicox S.A.
Patent: US6696591 B1, 2004 ;
Location in patent: Page column 5-6 ;
