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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1,2,4-三氮唑
合成路线
(共 394 条)
288-88-0
1,2,4-三氮唑
+
446-52-6
2-氟苯甲醛
→
反应条件
138479-53-5
2-(1H-1,2,4-三唑-1-基)苯甲醛
反应条件
potassium carbonate in dimethyl sulfoxide T=100°C; 3 h;
参考文献
Rosevear, Judi; Wilshire, John F. K.
Australian Journal of Chemistry, 1991 , vol. 44, # 8 p. 1097 - 1114
288-88-0
1,2,4-三氮唑
+
98-59-9
对甲苯磺酰氯
→
反应条件
13578-51-3
1-(4-甲基苯基磺酰基)-1,2,4-噻唑
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
Law, Ho; Baussanne, Isabelle; Garcia Fernandez, Jose M.; Defaye, Jacques
Carbohydrate Research, 2003 , vol. 338, # 5 p. 451 - 453
288-88-0
1,2,4-三氮唑
+
30955-05-6
→
反应条件
13578-51-3
1-(4-甲基苯基磺酰基)-1,2,4-噻唑
反应条件
ClPhOPOCl2 in pyridine 72 h; Ambient temperatureother reagents, solvent;
参考文献
Kasnar, Biserka; Krizmanic, Irena; Zinic, Mladen
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1067 - 1071
288-88-0
1,2,4-三氮唑
+
17201-43-3
对氰基溴化苄
→
反应条件
112809-27-5
+
112809-25-3
反应条件
potassium carbonate; potassium iodide in acetone T=55°C; 8 h; Product distribution / selectivity;
参考文献
Haider, Hussain; Solanki, Kirtipalsinh Saijansinh; Pal, Gautam; Singh, Manoj Kumar; Kothari, Jay Shantilal; Agarwal, Virendra Kumar
Patent: US2010/190997 A1, 2010 ;
Location in patent: Page/Page column 6 ;
288-88-0
1,2,4-三氮唑
+
69545-39-7
→
反应条件
112809-52-6
+
112809-51-5
反应条件
potassium carbonate in N,N-dimethyl-formamide; toluene T=60 - 80°C; 1.5 h; Product distribution / selectivity;
参考文献
US2007/112202 A1, ;
Page/Page column 7 ;
288-88-0
1,2,4-三氮唑
+
935477-95-5
→
反应条件
112809-51-5
反应条件
1: 1H-1,2,4-triazol With tetrabutylammomium bromide; potassium carbonate in water; isobutyl methylketone 2 h; 2: toluene-4-sulfonic acid bis-(4-cyano-phenyl)-methyl ester in water; isobutyl methylketone T=20 - 30°C; 48 h; 3: With hydrogenchloride in water; isobutyl methylketone 1 h;
参考文献
Palle, Venkata Raghavendra Acharyulu; Kalaria, Ashok Jerambhai; Shelke, Sandip Ashok
Patent: US2007/100149 A1, 2007 ;
Location in patent: Page/Page column 7 ;
288-88-0
1,2,4-三氮唑
+
112809-57-1
→
反应条件
112809-51-5
反应条件
potassium carbonate in N,N-dimethyl-formamide; toluene T=60 - 80°C; 4 h;
参考文献
CHEMAGIS LTD.
Patent: US2007/112202 A1, 2007 ;
Location in patent: Page/Page column 5; 7 ;
288-88-0
1,2,4-三氮唑
+
69545-39-7
→
反应条件
112809-52-6
+
112809-51-5
反应条件
potassium carbonate in N,N-dimethyl-formamide; toluene T=60 - 80°C; 1.5 h; Product distribution / selectivity;
参考文献
US2007/112202 A1, ;
Page/Page column 7 ;
288-88-0
1,2,4-三氮唑
+
69545-39-7
→
反应条件
112809-51-5
反应条件
tetrabutylammomium bromide; potassium carbonate in isopropyl alcohol 8 - 9 h; Heating / reflux; Product distribution / selectivity;
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala, kishan; RACHAKONDA, Srinivas; ADIBHATLA KALI SATYA, Bhujanga, Rao; VENKAIAH CHOWDARY, Nannapaneni
Patent: WO2007/144896 A1, 2007 ;
Location in patent: Page/Page column 7; 10 ;
288-88-0
1,2,4-三氮唑
+
446-52-6
2-氟苯甲醛
→
反应条件
138479-54-6
反应条件
potassium carbonate in dimethyl sulfoxide T=100°C; 10 h;
参考文献
Rosevear, Judi; Wilshire, John F. K.
Australian Journal of Chemistry, 1991 , vol. 44, # 8 p. 1097 - 1114
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