3-(4-甲氧苯基)-3-氧代丙酸乙酯合成路线 （共 58 条）
反应条件
triethylamine; magnesium chloride 1.) MeCN, 20 to 25 deg C, 2.5 h, 2.) 20 to 25 deg C, 12 h; Multistep reaction;
参考文献
Clay; Collom; Karrick; Wemple
Synthesis, 1993 , # 3 p. 290 - 292
反应条件
sodium hydride 1.) DMF, mineral oil, 15 min, 2.) DMF, mineral oil, heating; Yield givenMultistep reaction;
参考文献
Karnik, A. V.; Rane, J. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998 , vol. 37, # 11 p. 1191 - 1193
反应条件
(i) nBuLi, THF, hexane, (ii) /BRN= 471918/; Multistep reaction;
参考文献
Wierenga,W.; Skulnick,H.I.
Journal of Organic Chemistry, 1979 , vol. 44, # 2 p. 310 - 311
反应条件
0.0583333 h; microwave irradiation;
参考文献
Seijas, Julio A.; Vazquez-Tato, M. Pilar; Carballido-Reboredo, Raquel
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2855 - 2858
参考文献
Schoonjans
Chem. Zentralbl., 1897 , vol. 68, # II p. 616
反应条件
1: With pyridine; iodine; copper(II) oxide 18 h; Reflux; 2: With potassium carbonate 10 h; Reflux;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 81, # 3 p. 369 - 372
参考文献
Stepanow; Dawydowa
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 891,894; engl. Ausg. S. 864, 866
反应条件
1: 88 percent / aq. NaNO2, AcOH / 2 h 2: 85 percent / conc. aq. HCl, H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature 3: 88 percent / Et3N / CH2Cl2 / Ambient temperature 4: 47 percent / aq. NaOH / ethanol / 0.5 h / Ambient temperature 5: 31 percent / CoCl2*6H2O / H2O / 6 h / 33 - 41 °C / aminoacylase, pH = 7.0 6: NaNO2, KBr, aq. H2SO4 / diethyl ether / 2 h / Ambient temperature 7: diethyl ether / 0.17 h / Ambient temperature 8: 74 percent / K2CO3 / methanol; diethyl ether / 0.5 h / 0 - 5 °C View Scheme
参考文献
Inoue; Matsuki; Oh-Ishi
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 9 p. 1521 - 1523
反应条件
pyridine; hydroxylamine hydrochloride in ethanol Reflux;
参考文献
Kafle, Bhooshan; Aher, Nilkanth G.; Khadka, Deegendra; Park, Hwangseo; Cho, Hyeongjin
Chemistry - An Asian Journal, 2011 , vol. 6, # 8 p. 2073 - 2079
反应条件
1: hydroxylamine hydrochloride / ethanol / 0.75 h / Reflux 2: trichlorophosphate / 1.5 h / 70 - 80 °C View Scheme
参考文献
Rajender, P. Sarita; Sridevi; Reddy, K. Kondal
Synthetic Communications, 2012 , vol. 42, # 15 p. 2191 - 2200
