3-溴苯并噻吩-2-羧酸合成路线 （共 13 条）
反应条件
bromine; sodium acetate; acetic acid T=55 - 60°C; 24 h; Inert atmosphere;
参考文献
Rao, Manam Sreenivasa; Haritha, Meda; Chandrasekhar; Basaveswara Rao, Mandava V.; Pal, Manojit
Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1660 - 1663
反应条件
sulfur dioxide; hydrogen bromide in diethyl ether T=15 - 20°C; 20 h; 1) 5-10 deg C, 1 h, 2) 18-20 deg C, 20 h;
参考文献
Zborovskii, Yu. L.; Smirnov-Zamkov, I. V.; Staninets, V. I.
Journal of Organic Chemistry USSR (English Translation), 1984 , p. 1617 - 1625
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 8 p. 1774 - 1784
反应条件
n-butyllithium; diethyl ether anschliessend Behandeln mit festem Kohlendioxid;
参考文献
Tietze, Lutz F.; Lohmann, J. Klaas
Synlett, 2002 , # 12 p. 2083 - 2085
反应条件
potassium permanganate; acetone
参考文献
Tietze, Lutz F.; Lohmann, J. Klaas
Synlett, 2002 , # 12 p. 2083 - 2085
反应条件
1.1: Br2; NaOAc / CH2Cl2 / 0 °C 2.1: nBuLi / diethyl ether / -78 °C 2.2: diethyl ether / -78 °C 3.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / acetone View Scheme
参考文献
Ried; Bender
Chemische Berichte, 1955 , vol. 88, p. 34,36
反应条件
n-butyllithium Yield given. Multistep reaction;
参考文献
Reinecke, Manfred G.; Newsom, James G.; Almqvist, K. Anders
Synthesis, 1980 , # 4 p. 327 - 329
反应条件
1: chloroform; bromine 2: aqueous acetone; potassium permanganate View Scheme
参考文献
Ried; Bender
Chemische Berichte, 1955 , vol. 88, p. 34,36
反应条件
benzotriazol-1-ol in N,N-dimethyl-formamide T=20°C; Inert atmosphereCooling;
参考文献
INDIAN INSTITUTE OF SCIENCE; NATIONAL INSTITUTE OF IMMUNOLOGY
Patent: US2012/16014 A1, 2012 ;
Location in patent: Page/Page column 7 ;
US 20120016014 A1
反应条件
benzotriazol-1-ol in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
INDIAN INSTITUTE OF SCIENCE; NATIONAL INSTITUTE OF IMMUNOLOGY
Patent: US2012/16014 A1, 2012 ;
Location in patent: Page/Page column 7-8 ;
US 20120016014 A1
反应条件
hydrogenchloride 72 h;
参考文献
Zborovskii, Yu. L.; Smirnov-Zamkov, I. V.; Staninets, V. I.
Journal of Organic Chemistry USSR (English Translation), 1984 , p. 1617 - 1625
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 8 p. 1774 - 1784
