2-甲基-3-氧代己酸乙酯合成路线 （共 19 条）
反应条件
hydrogenchloride in ethanol
参考文献
Bestmann,H.J. et al.
Chemische Berichte, 1970 , vol. 103, p. 2794 - 2801
参考文献
Bulletin des Societes Chimiques Belges, , vol. 59, p. 689
反应条件
n-butyllithium; sodium hydride in tetrahydrofuran
T=0°C; 1 h;
参考文献
Ishibashi, Yasuharu; Ohba, Shigeru; Nishiyama, Shigeru; Yamamura, Shosuke
Tetrahedron Letters, 1996 , vol. 37, # 17 p. 2997 - 3000
反应条件
1: 2-methyl-3-oxobutanoic acid ethyl ester With sodium hydride in tetrahydrofuran; mineral oil
T=0°C;
2: With n-butyllithium in tetrahydrofuran; mineral oil
T=0°C; 0.666667 h;
3: ethyl halide Further stages;
参考文献
Chan, Yinman; Balle, Jared; Kevin Sparrow; Boyd, Peter D.W.; Brimble, Margaret A.; Barker, David
Tetrahedron, 2010 , vol. 66, # 35 p. 7179 - 7191
反应条件
1: T=80°C; Eschenmoser coupling;
2: With triethylamine; tris-(dimethylamino)-phosphine in acetonitrile
Heating;
参考文献
Bellec, Christian; Gaurat, Olivier
Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1289 - 1293
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
1) 20 min, -78 deg C, 2) l.5 h, r.t.;
参考文献
Tsuzuki, Kazuo; Akeyoshi, Masaharu; Omura, Satoshi
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 1 p. 395 - 396
反应条件
triethylamine; triethyl phosphite in acetonitrile
Heating;
参考文献
Bellec, Christian; Gaurat, Olivier
Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1289 - 1293
反应条件
triethylamine; triphenylphosphine in acetonitrile
Heating;
参考文献
Bellec, Christian; Gaurat, Olivier
Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1289 - 1293
反应条件
2: 58 percent / Lithium hexamethyldisilazanide / tetrahydrofuran / 1) 20 min, -78 deg C, 2) l.5 h, r.t.
View Scheme
参考文献
Tsuzuki, Kazuo; Akeyoshi, Masaharu; Omura, Satoshi
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 1 p. 395 - 396
反应条件
1: Et3N / diethyl ether / Heating
2: Ph3P, KOCMe2Et / dimethylsulfoxide; benzene
View Scheme
参考文献
Roth,M. et al.
Helvetica Chimica Acta, 1971 , vol. 54, p. 710 - 734
