1,4,8,11-四氮杂环十四烷合成路线 （共 60 条）
反应条件
1: 1,4,8,11-tetraazacyclo-tetradecane With formaldehyd; water 2: methyl iodide in acetonitrile 3: With sodium hydroxide in chloroform
参考文献
Comba, Peter; Gahan, Lawrence R.; Hanson, Graeme R.; Mereacre, Valeriu; Noble, Christopher J.; Powell, Annie K.; Prisecaru, Ion; Schenk, Gerhard; Zajaczkowski-Fischer, Marta
Chemistry - A European Journal, 2012 , vol. 18, # 6 p. 1700 - 1710
反应条件
potassium carbonate in chloroform T=20°C; 18 h;
参考文献
Helps; Parker; Morphy; Chapman
Tetrahedron, 1989 , vol. 45, # 1 p. 219 - 226
反应条件
tris(N,N-dimethylamino)borane; sodium hydride 1) toluene, reflux, 2) THF, 0 deg C, 30 min, 3) THF, 0 deg C then RT, 12 h; Yield given. Multistep reaction;
参考文献
Maillet; Kwok; Noujaim; Snieckus
Tetrahedron Letters, 1998 , vol. 39, # 18 p. 2659 - 2662
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
Helps; Parker; Morphy; Chapman
Tetrahedron, 1989 , vol. 45, # 1 p. 219 - 226
反应条件
in N,N-dimethyl-formamide
T=110 - 120°C; 2 h;
参考文献
Meunier, I.; Mishra, A. K.; Hanquet, B.; Cocolios, P.; Guilard, R.
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 685 - 695
反应条件
in ethanol; acetonitrile
12 h; Heating;
参考文献
De Santis, Giancarlo; Di Casa, Michela; Mariani, Mario; Seghi, Barbara; Fabbrizzi, Luigi
Journal of the American Chemical Society, 1989 , vol. 111, # 7 p. 2422 - 2427
反应条件
1: 97 percent / aq. methanol / 0.5 h / 0 °C
2: 93 percent / diisobutyl aluminium hydride / toluene / 96 h / Heating
View Scheme
参考文献
Yamamoto,H.; Maruoka,K.
Journal of the American Chemical Society, 1981 , vol. 103, p. 4186
反应条件
in water
T=0 - 20°C; 2 h; Product distribution / selectivity;
参考文献
Kyungpook National University Industry- Academic Cooperation Foundation
Patent: EP2476683 A2, 2012 ;
Location in patent: Page/Page column 27-28 ;
反应条件
formaldehyd in water
T=20°C;
参考文献
Dale, Ajit V.; Pandya, Darpan N.; Kim, Jung Young; Lee, Hochun; Ha, Yeong Su; Bhatt, Nikunj; Kim, Jonghee; Seo, Jeong Ju; Lee, Woonghee; Kim, Sung Hong; Yoon, Young-Ran; An, Gwang Il; Yoo, Jeongsoo
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 927 - 931
参考文献
Guilard, Roger; Bessmertnykh, Alla G.; Beletskaya, Irina P.
Synlett, 1997 , vol. 1997, # 10 p. 1190 - 1192
