1-溴-3-甲氧基-5-甲苯合成路线 （共 31 条）
反应条件
(i) aq. NaNO2, aq. HBr, (ii) CuBr; Multistep reaction;
参考文献
US3671636 , ;
Chem.Abstr., , vol. 77, # 88083
反应条件
potassium fluoride; water; copper(II) oxide T=250°C;
参考文献
Repinskaya, I. B.; Koptyug, V. A.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 7 p. 1298 - 1303
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 7 p. 1508 - 1514
反应条件
1: 16 percent / copper(II) nitrate trihydrate, acetic anhydride / 1.5 h / 30 °C 2: 8 percent / potassium carbonate, copper(II) oxide / 16 h / 140 °C View Scheme
参考文献
Carvalho, Christopher F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1613 - 1620
反应条件
1: 26 percent / copper(II) nitrate trihydrate, acetic anhydride / 1.5 h / 30 °C 2: 17 percent / potassium carbonate, copper(II) oxide / 16 h / 140 °C View Scheme
参考文献
Carvalho, Christopher F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1613 - 1620
反应条件
1: 50 percent / aq. KMnO4; pyridine / 24 h / 75 °C 2: 81 percent / LiAlH4 / diethyl ether / 3 h / 20 °C View Scheme
参考文献
Claudi, Francesco; Di Stefano, Antonio; Napolitani, Fabrizio; Cingolani, Gian Mario; Giorgioni, Gianfabio; Fontenla, Jose A.; Montenegro, Gisela Y.; Rivas, Maria E.; Rosa, Elizabeth; Michelotto, Barbara; Orlando, Giustino; Brunetti, Luigi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 599 - 608
参考文献
Dubinin
Zhurnal Obshchei Khimii, 1937 , vol. 7, p. 2183,2187
Chem. Zentralbl., 1938 , vol. 109, # I p. 3909
反应条件
1: 16 percent / copper(II) nitrate trihydrate, acetic anhydride / 1.5 h / 30 °C 2: 1.) hydrogen / 1.) palladized charcoal / 1.) ethanol, 18 h View Scheme
参考文献
Carvalho, Christopher F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1613 - 1620
反应条件
sodium methylselenolate in N,N,N',N',N'',N''-hexamethylphosphoric triamide 8 h; Heating;
参考文献
Evers, Michel; Christiaens, Leon
Tetrahedron Letters, 1983 , vol. 24, # 4 p. 377 - 380
反应条件
1: 52 percent / copper(II) nitrate trihydrate, acetic anhydride / 1.5 h / 30 °C 2: 16 percent / potassium carbonate, copper(II) oxide / 16 h / 140 °C View Scheme
参考文献
Carvalho, Christopher F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1613 - 1620
反应条件
pyridine; potassium permanganate T=75°C; Oxidation; 24 h;
参考文献
Marchais-Oberwinkler, Sandrine; Krachten, Patricia; Frotscher, Martin; Ziegler, Erika; Neugebauer, Alexander; Bhoga, Umadevi; Bey, Emmanuel; Mueller-Vieira, Ursula; Messinger, Josef; Thole, Hubert; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4685 - 4698
