4-(1-哌啶基甲基)苯胺合成路线 （共 6 条）
反应条件
platinum(IV) oxide; hydrogen in ethanol P=2585.81 Torr; 16 h;
参考文献
Nguyen, Thuy; Sakasegawa, Yuji; Doh-Ura, Katsumi; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2917 - 2929
反应条件
1: 100 percent / tetrahydrofuran / 20 °C 2: 75 percent / H2 / 10percent Pd/C / ethyl acetate / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 10 p. 2049 - 2063
反应条件
1: 100 percent / tetrahydrofuran / 20 °C 2: 75 percent / H2 / 10percent Pd/C / ethyl acetate / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 10 p. 2049 - 2063
反应条件
1: NaBH(OAc)3 / CH2Cl2 2: 37 percent / H2 / Pd/C / ethyl acetate; methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 4 p. 989 - 994
反应条件
1: 70 percent / K2CO3 / acetone / 12 h / Heating 2: 65 percent / hydrazine hydrate / Raney Ni / methanol View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 25, p. 877 - 879
反应条件
1: 4-piperidin-1-ylmethyl-phenylamine; 2-nitro-benzaldehyde in methanol
T=10 - 20°C; 1 h;
2: With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; water in methanol
T=10 - 20°C; pH=1 - 9; 1 h;
3: 1,1'-carbonyldiimidazole With hydrogen; nickel
more than 3 stages;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/77931 A2, 2005 ;
Location in patent: Page/Page column 10-12 ;
WO 2005/077931 A2
