1,4-苯并二恶烷-6-甲醛合成路线 （共 44 条）
反应条件
hydroxylamine hydrochloride; sodium acetate in ethanol 12 h;
参考文献
Oh, Yoo Na; Kwak, Jumyung; Koh, Hun Yeong; Jung, Sun Ho
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 12 p. 4227 - 4230
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 20 °C 2: hydrogenchloride; hydrogen; 5 palladium on charcoal / ethanol / 20 °C / 760.05 Torr View Scheme
参考文献
Su, Bo; Deng, Meng; Wang, Qingmin
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 977 - 981
反应条件
ammonium acetate; malonic acid in ethanol
参考文献
Queen's University at Kingston
Patent: US2003/114441 A1, 2003 ;
参考文献
Wehner, Volkmar; Blum, Horst; Kurz, Michael; Stilz, Hans Ulrich
Synthesis, 2002 , # 14 p. 2023 - 2036
反应条件
malonic acid in pyridine; sodium hydroxide
参考文献
KISSEI PHARMACEUTICAL CO., LTD.
Patent: EP855387 A1, 1998 ;
反应条件
piperidine; pyridine
参考文献
Dobrowsky
Monatshefte fuer Chemie, 1951 , vol. 82, p. 122,134
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux; Industry scale 2.1: magnesium; 2-monochloropropane / ethyl bromide; iodine; isopropylmagnesium chloride / tetrahydrofuran / 0 - 70 °C / Industry scale 2.2: 8.5 h / -5 - 55 °C / Industry scale 3.1: triethylsilane / dichloromethane / 20 °C / Industry scale 3.2: -5 - 20 °C / Industry scale 4.1: caesium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 0 - 25 °C / Industry scale View Scheme
参考文献
XENON PHARMACEUTICALS INC.
Patent: US2011/87027 A1, 2011 ;
反应条件
1: 61 percent / Br2 / acetic acid / 0 °C 2: 49 percent / CuCl2 / dimethylformamide / 100 °C 3: 97 percent / AlCl3 / CH2Cl2 / 25 °C View Scheme
参考文献
Guillaumet, G.; Hretani, M.; Coudert, G.
Tetrahedron Letters, 1988 , vol. 29, # 22 p. 2665 - 2666
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 1.2: 4 h / |Acidic conditions 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 11 h / |Reflux View Scheme
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
1: 61 percent / Br2 / acetic acid / 0 °C 2: 49 percent / CuCl2 / dimethylformamide / 100 °C View Scheme
参考文献
Taniguchi, Eiji; Yamauchi, Satoshi; Nagata, Shyuichirou; Ohnishi, Takeshi
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 2.3.4. p. 630 - 635
