4-(三氟甲基)苯甲酸甲酯合成路线 （共 48 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in chloroform 5 h; Heating;
参考文献
Journal of Physical Organic Chemistry, , vol. 7, p. 31 - 42
反应条件
1: With phenyl silane; potassium hydroxide T=20°C; 0.5 h; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C; 1 h;
参考文献
Fernandez-Salas, Jose A.; Manzini, Simone; Nolan, Steven P.
Chemical Communications, 2013 , vol. 49, # 84 p. 9758 - 9760
反应条件
1: With sodium methylate in N,N-dimethyl-formamide T=-10°C; 26 h; 2: With sulfuric acid in tert-butyl methyl ether; water; N,N-dimethyl-formamide T=-8.5 - 20°C;
参考文献
Schering Corporation
Patent: US2003/208074 A1, 2003 ;
Location in patent: Page/Page column 8; 15 ;
反应条件
hydrazine hydrate Ambient temperature;
参考文献
Tavares; Penna; Amaral
Bollettino Chimico Farmaceutico, 1997 , vol. 136, # 3 p. 244 - 249
反应条件
1: [(1,3-bis(2,4,6-trimethylphenyl) imidazol-2-ylidene)Fe(CO)4] / toluene / 3 h / 20 °C / |Schlenk technique; |Inert atmosphere; |UV-irradiation 2: hydrogenchloride; water / toluene; tetrahydrofuran / 2 h / 20 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Li, Haoquan; Misal Castro, Luis C.; Zheng, Jianxia; Roisnel, Thierry; Dorcet, Vincent; Sortais, Jean-Baptiste; Darcel, Christophe
Angewandte Chemie - International Edition, 2013 , vol. 52, # 31 p. 8045 - 8049
Angew. Chem., 2013 , vol. 125, # 31 p. 8203 - 8207
反应条件
potassium tert-butylate in tetrahydrofuran Ambient temperature;
参考文献
Stanton, Matthew G.; Gagne, Michel R.
Journal of Organic Chemistry, 1997 , vol. 62, # 23 p. 8240 - 8242
反应条件
sodium t-butanolate in tetrahydrofuran Rate constant;
参考文献
Stanton, Matthew G.
Journal of the American Chemical Society, 1998 , vol. 120, # 24 p. 5981 - 5989
反应条件
NH4Br; potassium bromide in ammonia T=-38°C; electrochemical reduction, various reaction conditions; Rate constantMechanism;
参考文献
Andrieux, Claude P.; Combellas, Catherine; Kanoufi, Frederic; Saveant, Jean-Michel; Thiebault, Andre
Journal of the American Chemical Society, 1997 , vol. 119, # 40 p. 9527 - 9540
反应条件
methyl-magnesium iodide
参考文献
Merck and Co., Inc.
Patent: US5877191 A1, 1999 ;
US 5877191 A
反应条件
1: With acetonitrile in chlorobenzene 30 h; 2: With sodium methylate
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/785 A2, 2003 ;
Location in patent: Page 25 ;
WO 2004/000785 A2
