4-(2-苯基-1-乙炔)苯甲腈合成路线 （共 64 条）
反应条件
1: PPh3 / CH2Cl2 / 1 h / 25 °C
2: 91 percent / Pd2(dba)3; TFP; DIPEA / dimethylformamide / 10 h / 80 °C
View Scheme
参考文献
Shen, Wang; Wang, Le
Journal of Organic Chemistry, 1999 , vol. 64, # 24 p. 8873 - 8879
反应条件
anhydrous copper acetate in 1,3-dimethyl-imidazolidin-2-one
T=120°C; 12 h; Inert atmosphere;
参考文献
Ihara, Hideki; Ueda, Akinori; Suginome, Michinori
Chemistry Letters, 2011 , vol. 40, # 9 p. 972 - 974
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
triphenylphosphine in tetrahydrofuran
T=70°C; Negishi Coupling; 24 h; Inert atmosphereGreen chemistry; Catalytic behavior;
参考文献
Wu, Wei-Yi; Lin, Tze-Chiao; Takahashi, Tamotsu; Tsai, Fu-Yu; Mou, Chung-Yuan
ChemCatChem, 2013 , vol. 5, # 4 p. 1011 - 1019
反应条件
tetra-n-butylammonium acetate; Pd nanocluster from Pd(OAc) in N,N-dimethyl-formamide
T=50°C; Sonogashira cross-coupling; 6 h; Kinetics; Further Variations:Catalysts;
参考文献
Thathagar, Mehul B.; Kooyman, Patricia J.; Boerleider, Romilda; Jansen, Eveline; Elsevier, Cornelis J.; Rothenberg, Gadi
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 15 p. 1965 - 1968
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate in tetrahydrofuran; water
15 h; Reflux;
参考文献
Lennox, Alastair J. J.; Lloyd-Jones, Guy C.
Journal of the American Chemical Society, 2012 , vol. 134, # 17 p. 7431 - 7441
反应条件
hydrogenchloride; sodium nitrite
1.) water, poly(ethylene glycol), CH2Cl2, 0 deg C; 2.) poly(ethylene glycol), CH2Cl2, from 0 deg C to RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Suzuki, Nobutaka; Azuma, Terukazu; Kaneko, Yoshihiro; Izawa, Yasuji; Tomioka, Hideo; Nomoto, Tateo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 645 - 648
反应条件
hydrogenchloride; sodium nitrite
multistep reaction; diazotization and Sandmeyer reaction in polyethylene glycol-CH2Cl2; 0 deg C to r.t.;
参考文献
Suzuki, Nobutaka; Kaneko, Yoshihiro; Nomoto, Tateo; Izawa, Yasuji
Journal of the Chemical Society, Chemical Communications, 1984 , # 22 p. 1523 - 1524
反应条件
sodium tetrahydroborate; palladium on activated charcoal in ethanol
T=10°C; 2 h; Yield given. Yields of byproduct given;
参考文献
Suzuki, N.; Kaneko, Y.; Tsukanaka, T.; Nomoto, T.; Ayaguchi, Y.; Izawa, Y.
Tetrahedron, 1985 , vol. 41, # 12 p. 2387 - 2392
