3,4-二甲氧基-5-羟基苯甲醛合成路线 （共 37 条）
反应条件
nitrogen(IV) oxide in water Irradiationfurther pH, radiolytic method, pH=3; Product distribution;
参考文献
Tetrahedron, , vol. 49, # 43 p. 9689 - 9698
反应条件
3-Methylpyridine in para-xylene T=160°C; 25 h; Product distribution / selectivity;
参考文献
ARPIDA AG
Patent: WO2005/14586 A1, 2005 ;
Location in patent: Page/Page column 9; 10 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide 2 h; Inert atmosphere;
参考文献
Androutsopoulos, Vasilis P.; Ruparelia, Ketan C.; Papakyriakou, Athanasios; Filippakis, Harilaos; Tsatsakis, Aristeidis M.; Spandidos, Demetrios A.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2586 - 2595
参考文献
Nakamura, Tomofumi; Ichinose, Hirofumi; Wariishi, Hiroyuki
Biochemical and Biophysical Research Communications, 2010 , vol. 394, # 3 p. 470 - 475
反应条件
1: K2CO3 / dimethylformamide / 4 h / 70 °C
2: NaBH4 / methanol / 0.17 h / 20 °C
3: PBr3 / diethyl ether / 1 h / 20 °C
View Scheme
参考文献
Sakakibara, Norikazu; Suzuki, Shiro; Umezawa, Toshiaki; Shimada, Mikio
Organic and biomolecular chemistry, 2003 , vol. 1, # 14 p. 2474 - 2485
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C
3: sodium hydroxide / methanol / 3 h / 20 °C
4: potassium carbonate / acetone
View Scheme
参考文献
Huang, Guan-Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping-Chung; Huang, Chieh-Hung; Shih, Hung-Cheng; Lee, E.-Jian; Yang, Mei-Lin; Leu, Yann-Lii; Wu, Tian-Shung
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 371 - 378
反应条件
1: 1.) HCO3H; 2.) 5 percent KOH / 1.) formic acid; 2.) ether
2: 1.8 g / K2CO3 / dimethylformamide / 1 h / 120 °C / Heating
View Scheme
参考文献
Iinuma; Tanaka; Ito; Mizuno
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 660 - 667
反应条件
formic acid; peroxyformic acid; potassium carbonate
2.) DMF; Multistep reaction;
参考文献
Iinuma, Munekazu; Tanaka, Toshiyuki; Matsuura, Shin
Heterocycles, 1983 , vol. 20, # 12 p. 2425 - 2428
反应条件
1: 1.) HCO3H; 2.) 5 percent KOH / 1.) formic acid; 2.) ether
2: 1.8 g / K2CO3 / dimethylformamide / 1 h / 120 °C / Heating
3: 400 mg / POCl3 / Ambient temperature
View Scheme
参考文献
Iinuma; Tanaka; Ito; Mizuno
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 660 - 667
反应条件
potassium carbonate; potassium iodide in acetone
0.25 h; Heating;
参考文献
Jacob, Peyton; Shulgin, Alexander T.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 881 - 888
