四氢吡喃酮合成路线

参考文献

Pfizer Inc
Patent: US2009/30003 A1, 2009 ;
Location in patent: Page/Page column 35-36 ;
US 20090030003 A1

29943-42-8四氢吡喃酮

693287-79-52-(四氢吡喃-4-基)肼基甲酸叔丁酯

参考文献

PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; JAQUITH, James B.
Patent: WO2013/177668 A1, 2013 ;

29943-42-8四氢吡喃酮+

870-46-2肼基甲酸叔丁酯+

64-19-7醋酸

90271-04-82-甲基-2-丙基2-乙酰基肼羧酸酯+

693287-79-52-(四氢吡喃-4-基)肼基甲酸叔丁酯

参考文献

Verhoest, Patrick R.; Fonseca, Kari R.; Hou, Xinjun; Proulx-Lafrance, Caroline; Corman, Michael; Helal, Christopher J.; Claffey, Michelle M.; Tuttle, Jamison B.; Coffman, Karen J.; Liu, Shenpinq; Nelson, Frederick; Kleiman, Robin J.; Menniti, Frank S.; Schmidt, Christopher J.; Vanase-Frawley, Michelle; Liras, Spiros
Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9045 - 9054

29943-42-8四氢吡喃酮+

1099-45-2乙氧甲酰基亚甲基三苯基膦

894789-84-52-(4-甲基四氢-2H-吡喃-4-基)乙酸

参考文献

Vertex Pharmaceuticals Incorporated
Patent: US2010/272681 A1, 2010 ;

29943-42-8四氢吡喃酮

894789-84-52-(4-甲基四氢-2H-吡喃-4-基)乙酸

参考文献

GENENTECH,INC.; FORMA TM, LLC; YUEN, Po-Wai; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; DRAGOVICH, Peter; LIU, Xiongcai; PATEL, Snahel; ZAK, Mark; ZHAO, Guiling; ZHANG, Yamin; ZHENG, Xiaozhang
Patent: WO2013/127269 A1, 2013 ;

29943-42-8四氢吡喃酮+

371-40-44-氟苯胺

912545-21-2

参考文献

ASTEX THERAPEUTICS LIMITED
Patent: WO2006/109075 A2, 2006 ;
Location in patent: Page/Page column 90 ;

29943-42-8四氢吡喃酮+

626-35-7硝基乙酸乙酯

921755-40-02-(3,6-二氢-2H-吡喃-4-基)-2-硝基乙酸乙酯

参考文献

TARGACEPT, INC.
Patent: WO2006/23630 A2, 2006 ;
Location in patent: Page/Page column 38, 73 ;

29943-42-8四氢吡喃酮+

626-35-7硝基乙酸乙酯

921755-40-02-(3,6-二氢-2H-吡喃-4-基)-2-硝基乙酸乙酯

参考文献

Strachan, Jon-Paul; Whitaker, Regina C.; Miller, Craig H.; Bhatti, Balwinder S.
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9909 - 9911

29943-42-8四氢吡喃酮

921940-89-8

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PFIZER JAPAN INC.; PFIZER INC.
Patent: WO2007/10390 A1, 2007 ;
Location in patent: Page/Page column 27-28 ;
WO 2007/010390 A1

29943-42-8四氢吡喃酮

929556-48-9

参考文献

Meiji Seika Pharma Co., Ltd.; MORINAKA, Akihiro; MAEBASHI, Kazunori; IDA, Takashi; HIKIDA, Muneo; YAMADA, Mototsugu; ABE, Takao
Patent: EP2737900 A1, 2014 ;