1,5-二氢-6-甲基-4H-吡唑并[3,4-d]嘧啶-4-酮合成路线 (共 9 条)
反应条件
1: With PPA T=120°C; 6 h; 2: With sodium hydroxide in water T=20°C; pH=~ 5;
参考文献
WO2005/117909 A2, ;
Page/Page column 100 ;
WO 2005/117909 A2
反应条件
polyphosphate ester T=110 - 120°C; 6 h;
参考文献
Reddy, K Hemender; Reddy, A Panduranga; Veeranagaiah, V
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 3 p. 163 - 166
反应条件
1: 2: With trichlorophosphate 2.5 h; Reflux;
参考文献
Zhang, Xiaohong; Lin, Qiulian; Zhong, Ping
Molecules, 2010 , vol. 15, # 5 p. 3079 - 3086
反应条件
hydrogenchloride 6 h;
参考文献
Taylor, Edward C.; Patel, Hemantkumar H.
Tetrahedron, 1992 , vol. 48, # 37 p. 8089 - 8100
反应条件
dihydrogen peroxide; potassium hydroxide T=90°C; 1 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 455 - 464
参考文献
Journal of Organic Chemistry, , vol. 23, p. 191,195
反应条件
N,N-dimethyl-aniline; trichlorophosphate
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; FOLLMANN, Markus; STASCH, Johannes-Peter; REDLICH, Gorden; GRIEBENOW, Nils; LANG, Dieter; WUNDER, Frank; HÜBSCH, Walter; LINDNER, Niels; VAKALOPOULOS, Alexandros; TERSTEEGEN, Adrian
Patent: US2013/338137 A1, 2013 ;
Location in patent: Paragraph 1660; 1661; 1662; 1663 ;
反应条件
1: N,N-dimethyl-aniline; POCl3 2: ethanol; NH3 View Scheme
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1958 , vol. 23, p. 191,195
反应条件
1: N,N-dimethyl-aniline; POCl3 2: ethanol View Scheme
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1958 , vol. 23, p. 191,195