(1-甲基-1H-咪唑-2-基)苯甲酮合成路线 （共 19 条）
反应条件
triethylamine in acetonitrile T=5 - 20°C;
参考文献
BAYER CROPSCIENCE SA
Patent: WO2009/130193 A1, 2009 ;
Location in patent: Page/Page column 106-107 ;
反应条件
sodium hydride in tetrahydrofuran; mineral oil T=20°C; 1 h; Inert atmosphere; regioselective reaction;
参考文献
Zarganes-Tzitzikas, Tryfon; Neochoritis, Constantinos G.; Stephanidou-Stephanatou, Julia; Tsoleridis, Constantinos A.
Journal of Organic Chemistry, 2011 , vol. 76, # 5 p. 1468 - 1471
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=-78°C; 2: benzoic acid ethyl ester in tetrahydrofuran
参考文献
Samanta, Ramesh C.; De Sarkar, Suman; Froehlich, Roland; Grimme, Stefan; Studer, Armido
Chemical Science, 2013 , vol. 4, # 5 p. 2177 - 2184
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=-80°C; 2 h;
参考文献
Anders, Ernst; Boldt, Hans-Guenter; Fuchs, Renate; Gassner, Thomas
Tetrahedron Letters, 1984 , vol. 25, # 16 p. 1715 - 1716
反应条件
in diethyl ether T=20°C; 3 h;
参考文献
Abarca-Gonzalez, Belen; Jones, R. Alan; Medio-Simon, Mercedes; Quilez-Pardo, Juan; Sepulveda-Arques, Jose; Zaballos-Garcia, Elena
Synthetic Communications, 1990 , vol. 20, # 3 p. 321 - 331
反应条件
sodium acetate; pyridinium chlorochromate in dichloromethane T=20°C; 2 h; Yield given;
参考文献
Synthetic Communications, , vol. 20, # 3 p. 321 - 331
反应条件
1: diethyl ether / 20 °C 2: pyridinium chlorochromate, sodium acetate / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 20, # 3 p. 321 - 331
反应条件
1: 73 percent / 5 h / -14 °C 2: 22 percent / NaN(SiMe3)2 / tetrahydrofuran / 2 h / -80 °C View Scheme
参考文献
Chemische Berichte, , vol. 119, # 1 p. 279 - 296
反应条件
n-butyllithium 1.) THF, hexane, -78 deg C, 15 min; 2.) THF, allowed to r.t. during 30 min; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 12 p. 4916 - 4926
反应条件
n-butyllithium 1.) hexane, THF, -78 deg C, 10 min, 2.) hexane, THF, from -78 to 20 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 23, # 7 p. 1759 - 1764
