1-溴-2-甲基-1-丙烯合成路线 （共 93 条）
反应条件
sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; water
T=65°C; 10 h;
参考文献
Soderquist; Santiago; Rivera
Tetrahedron Letters, 1990 , vol. 31, # 35 p. 4981 - 4984
参考文献
Petrow; Nikischin
Zhurnal Obshchei Khimii, 1956 , vol. 26, p. 1233,1236;engl.Ausg.S.1395,1396
反应条件
pyridine; quinoline
T=200°C;
参考文献
Adams; Ferretti
Journal of the American Chemical Society, 1959 , vol. 81, p. 4927,4929
反应条件
aluminium trichloride
T=25°C; 0.5 h; other alkylation agents, var. time and temp. of reaction, other reagents; Product distributionMechanism;
参考文献
Khalaf, Ali Ali; Albar, Hassan A.
Journal of the Indian Chemical Society, 1995 , vol. 72, # 2 p. 87 - 92
反应条件
1: (phenylsulfonyl)methane With lithium hexamethyldisilazane in tetrahydrofuran
T=-20 - 20°C; Negishi coupling reaction; Inert atmosphere;
2: With zinc(II) chloride in tetrahydrofuran
T=-20 - 20°C; Negishi coupling reaction; 1 h; Inert atmosphere;
3: 1-bromo-2-methyl-1-propene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran
T=65°C; Negishi coupling reaction; Degassed under vacuumInert atmosphere;
参考文献
Zhou, Gang; Ting, Pauline C.; Aslanian, Robert G.
Tetrahedron Letters, 2010 , vol. 51, # 6 p. 939 - 941
反应条件
(i) Mg, Et2O, THF, (ii) /BRN= 2069980/; Multistep reaction;
参考文献
Karlsen; Froyen; Skattebol
Acta Chemica Scandinavica, 1976 , vol. 30, # 7 B p. 664 - 668
反应条件
in tetrahydrofuran
Ar-atmosphere; addn. of 0.5 equiv. ZnCl2 to organomagnesium derivative (prepd. from alkene bromide);
参考文献
Bourhis, Mireille; Bosc, Jean-Jacques; Golse, Rene
Journal of Organometallic Chemistry, 1983 , vol. 256, # 2 p. 193 - 202
反应条件
tert.-butyl lithium
1.) THF, pentane, -78 to 5 deg C, 90 min, 2.) THF, rt, 15 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wilson; Davey; Guazzaroni
Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 2007 - 2012
反应条件
copper(l) iodide; 3,4,7,8-tetra-methyl-1,10-phenanthroline; caesium carbonate in toluene
T=80°C; 48 h;
参考文献
Nordmann, Gero; Buchwald, Stephen L.
Journal of the American Chemical Society, 2003 , vol. 125, # 17 p. 4978 - 4979
反应条件
tri-n-butyltin methoxide; bis (triortho-tolylphosphine)palladium(II) chloride in toluene
T=100°C; 0.5 h;
参考文献
Kosugi, Masanori; Hagiwara, Isao; Migita, Toshihiko
Chemistry Letters, 1983 , p. 839 - 840
