o-羟基-alpha,alpha-二甲基苄醇合成路线 （共 24 条）
反应条件
1: 98 percent / Br2 / CCl4 / 0 °C 2: 1.3 g / DBN / diethyl ether / 10 h / 0 °C 3: 92 percent / KF / methanol / 2 h / 0 °C 4: 92 percent / phosphate buffer / tetrahydrofuran; H2O / pH 7.0 View Scheme
参考文献
Chao, Herbert S.-I.; Berchtold, Glenn A.
Journal of the American Chemical Society, 1981 , vol. 103, # 4 p. 898 - 902
反应条件
1: 92 percent / KF / methanol / 2 h / 0 °C 2: 92 percent / phosphate buffer / tetrahydrofuran; H2O / pH 7.0 View Scheme
参考文献
Chao, Herbert S.-I.; Berchtold, Glenn A.
Journal of the American Chemical Society, 1981 , vol. 103, # 4 p. 898 - 902
反应条件
1: methyl iodide With iodine; magnesium in diethyl ether Grignard reaction; Reflux; 2: o-hydroxyacetophenone in diethyl ether T=0°C; Grignard reaction; 0.75 h; Reflux;
参考文献
Fan, Jinmin; Wang, Zhiyong
Chemical Communications, 2008 , # 42 p. 5381 - 5383
反应条件
in tetrahydrofuran Inert atmosphere;
参考文献
SUN PHARMA ADVANCED RESEARCH COMPANY LTD.; RATHOD, Rajendrasinh; BHATT, Tushar; JOSHI, Kiritkumar; DOLE, Binaka; MURTY, Kadiyala V.S.N; THENNATI, Rajamannar
Patent: WO2013/51024 A2, 2013 ;
Location in patent: Page/Page column 88 ;
参考文献
Hansen
Helvetica Chimica Acta, 1977 , vol. 60, # 6 p. 2007 - 2033
反应条件
borate buffer; anhydrous carbonate in tetrahydrofuran; water 72 h; other pH; Product distributionMechanism;
参考文献
Chao, Herbert S.-I.; Berchtold, Glenn A.
Journal of the American Chemical Society, 1981 , vol. 103, # 4 p. 898 - 902
反应条件
in diethyl ether 3 h; Heating;
参考文献
Biswas; Ghosh; Venkateswaran
Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1865 - 1874
参考文献
Hoering; Baum
Patent: DE208886 ;
反应条件
Yield given. Multistep reaction;
参考文献
Talley, John J.; Evans, Irene A.
Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5267 - 5269
参考文献
Hoering; Baum
Patent: DE208886 ;
