1: With potassium carbonate; palladium on activated carbon in N,N-dimethyl-formamide T=125 - 130°C; Heck Reaction; 5.25 h; 2: With hydrogenchloride in water T=20°C; 0.333333 - 1 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/125026 A2, 2006 ;
Location in patent: Page/Page column 22; 24 ;
1: With potassium carbonate; palladium diacetate in N,N-dimethyl-formamide T=90°C; 0.333333 h; microwave irradiation; 2: With hydrogenchloride in water 0.166667 h; Further stages.;
1: With potassium chloride; tetra-n-butylammonium acetate; palladium diacetate; potassium carbonate in N,N-dimethyl-formamide T=90°C; 2: With hydrogenchloride T=20°C; 0.166667 h;
参考文献
Esteves, Catia I. C.; Santos, Clementina M. M.; Brito, Cristela M.; Silva, Artur M. S.; Cavaleiro, Jose A. S.
Synlett, 2011 , # 10 art. no. D06911ST, p. 1403 - 1406
1: With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); sodium acetate in 1-methyl-pyrrolidin-2-one T=140°C; 6 h; 2: With hydrogenchloride; water in 1-methyl-pyrrolidin-2-one
