5-溴-2-吡啶羧酸合成路线

参考文献

OSLO UNIVERSITY HOSPITAL HF; HOLSWORTH, Daniel; WAALER, Jo; MACHON, Ondrej; KRAUSS, Stefan; VORONKOV, Andrey Edward; GOLDING, Louise
Patent: WO2012/76898 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/076898 A1

30766-11-15-溴-2-吡啶羧酸+

765-30-0环丙胺

638219-77-9N-环丙基-5-溴吡啶甲酰胺

参考文献

Gallant, Michel; Chauret, Nathalie; Claveau, David; Day, Stephen; Deschenes, Denis; Dube, Daniel; Huang, Zheng; Lacombe, Patrick; Laliberte, France; Levesque, Jean-Francois; Liu, Susana; Macdonald, Dwight; Mancini, Joseph; Masson, Paul; Mastracchio, Anthony; Nicholson, Donald; Nicoll-Griffith, Deborah A.; Perrier, Helene; Salem, Myriam; Styhler, Angela; Young, Robert N.; Girard, Yves
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 4 p. 1407 - 1412

123-75-1四氢吡咯+

30766-11-15-溴-2-吡啶羧酸

742085-70-71-(5-溴砒啶-2-基羰基)吡咯啉

参考文献

GLAXO GROUP LIMITED
Patent: WO2008/110566 A1, 2008 ;
Location in patent: Page/Page column 29 ;
WO 2008/110566 A1

30766-11-15-溴-2-吡啶羧酸

1312903-94-8

参考文献

OSLO UNIVERSITY HOSPITAL HF; HOLSWORTH, Daniel; WAALER, Jo; MACHON, Ondrej; KRAUSS, Stefan; VORONKOV, Andrey Edward; GOLDING, Louise
Patent: WO2012/76898 A1, 2012 ;
WO 2012/076898 A1

110-89-4哌啶+

30766-11-15-溴-2-吡啶羧酸

364794-78-55-溴-2-哌啶基-1-甲基吡啶

参考文献

Demont, Emmanuel Hubert; Garton, Neil Stuart; Gosmini, Romain Luc Marie; Hayhow, Thomas George Christopher; Seal, Jonathan; Wilson, David Matthew; Woodrow, Michael David
Patent: US2012/208798 A1, 2012 ;

30766-11-15-溴-2-吡啶羧酸

1201326-81-95-甲砜基吡啶-2-甲酸甲酯

参考文献

Voronkov, Andrew; Holsworth, Daniel D.; Waaler, Jo; Wilson, Steven R.; Ekblad, Bie; Perdreau-Dahl, Harmonie; Dinh, Huyen; Drewes, Gerard; Hopf, Carsten; Morth, Jens P.; Krauss, Stefan
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3012 - 3023

30766-11-15-溴-2-吡啶羧酸

137178-88-25-溴吡啶-2-甲酰氯

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/7041 A1, 2007 ;
Location in patent: Page/Page column 220-221 ;
WO 2007/007041 A1

67-56-1甲醇+

30766-11-15-溴-2-吡啶羧酸

29682-15-35-溴吡啶-2-羧酸甲酯

参考文献

WO2012/76898 A1, ;

Page/Page column 64-65 ;
WO 2012/076898 A1

30766-11-15-溴-2-吡啶羧酸+

18107-18-1三甲基硅烷化重氮甲烷

29682-15-35-溴吡啶-2-羧酸甲酯