2,5-二甲氧基-1,4-苯醌合成路线 （共 69 条）
反应条件
1: 5.50 mg / NaBH4 / ethanol / 3 h / 0 °C
2: 4.9 mg / NaOH; NaHSO3 / ethanol / 4 h / 70 - 80 °C
3: 74 percent / HBr; AcOH / 16 h / 20 °C
View Scheme
参考文献
Stahl, Petra; Waldmann, Herbert
Angewandte Chemie - International Edition, 1999 , vol. 38, # 24 p. 3710 - 3713
反应条件
1: 51 percent / Br2; Al2O3 / 48 h / 20 °C / sonication
2: 61 percent / LiN(TMS)2 / tetrahydrofuran / 3 h / -78 - 20 °C
3: 72 percent / s-BuLi / tetrahydrofuran / 2 h / -78 - 20 °C
4: 74 percent / NaOH / 4 h / 20 °C
5: 78 percent / KOH / H2O; ethanol / 2 h / Heating
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参考文献
Tatsuta; Mukai; Mitsumoto
Journal of Antibiotics, 2001 , vol. 54, # 1 p. 105 - 108
参考文献
Henry; Smith
Journal of the American Chemical Society, 1952 , vol. 74, p. 278
反应条件
aluminium trichloride
unter Kuehlung;
参考文献
Oliverio; Castelfranchi
Gazzetta Chimica Italiana, 1950 , vol. 80, p. 267
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Oliverio
Gazzetta Chimica Italiana, 1948 , vol. 78, p. 105,108
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Oliverio; Castelfranchi; Simonelli
Gazzetta Chimica Italiana, 1952 , vol. 82, p. 109,110 Anm. 3
参考文献
Oliverio; Castelfranchi
Gazzetta Chimica Italiana, 1950 , vol. 80, p. 267
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Oliverio
Gazzetta Chimica Italiana, 1948 , vol. 78, p. 105,108
Full Text Show Details
Oliverio; Castelfranchi; Simonelli
Gazzetta Chimica Italiana, 1952 , vol. 82, p. 109,110 Anm. 3
反应条件
aluminum oxide; bromine
0.0833333 h; Heatingmicrowave irradiation;
参考文献
Bansal, Vandana; Kanodia, Saraswati; Thapliyal, Prakash C.; Khanna, Rajinder N.
Synthetic Communications, 1996 , vol. 26, # 5 p. 887 - 892
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
T=20°C; 2 h; Inert atmosphere;
参考文献
Viault, Guillaume; Gree, Danielle; Das, Saibal; Yadav, Jhillu Singh; Gree, Rene
European Journal of Organic Chemistry, 2011 , # 7 p. 1233 - 1241
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane / 24 h / 110 °C / Inert atmosphere; Combinatorial reaction / High throughput screening (HTS)
3: boron tribromide / dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
Viault, Guillaume; Gree, Danielle; Das, Saibal; Yadav, Jhillu Singh; Gree, Rene
European Journal of Organic Chemistry, 2011 , # 7 p. 1233 - 1241
参考文献
Farbenfabr. Bayer
Patent: DE967794 , 1954 ;
Full Text Show Details
Petersen et al.
Angewandte Chemie, 1955 , vol. 67, p. 217,219
