1-Boc-4-(2-吡啶氧基)哌啶合成路线 （共 5 条）
反应条件
1: 1-(tert-Butyloxycarbonyl)-4-piperidinol With sodium hydride in 1-methyl-pyrrolidin-2-one T=20°C; 0.166667 h; 2: 2-bromo-pyridine in 1-methyl-pyrrolidin-2-one 6 h; Heating / reflux;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/105779 A1, 2005 ;
Location in patent: Page/Page column 38 ;
WO 2005/105779 A1
反应条件
18-crown-6 ether in toluene 18 h; Heating / reflux;
参考文献
PIRAMED LIMITED
Patent: WO2006/46031 A1, 2006 ;
Location in patent: Page/Page column 68 ;
WO 2006/046031 A1
反应条件
triphenylphosphine in tetrahydrofuran
参考文献
Shima, Ichiro; Ohkawa, Takehiko; Sato, Kentaro; Ishibashi, Naoki; Imamura, Kenichiro
Patent: US2004/97425 A1, 2004 ;
反应条件
hydrogen; ammonium formate; palladium 10 on activated carbon in methanol
参考文献
PIRAMED LIMITED
Patent: WO2006/46031 A1, 2006 ;
Location in patent: Page/Page column 68 ;
WO 2006/046031 A1
反应条件
hydrogenchloride; methanol; water T=20°C; 0.5 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/105779 A1, 2005 ;
Location in patent: Page/Page column 38 ;
WO 2005/105779 A1
