2-氯-4-(1-哌啶基)-苯甲酸合成路线 （共 3 条）
反应条件
1: With sodium hydroxide; water in methanol 0.75 h; Reflux; 2: With hydrogenchloride in methanol; water
参考文献
Tsukamoto, Issei; Koshio, Hiroyuki; Akamatsu, Seijiro; Kuramochi, Takahiro; Saitoh, Chikashi; Yatsu, Takeyuki; Yanai-Inamura, Hiroko; Kitada, Chika; Yamamoto, Eisaku; Sakamoto, Shuichi; Tsukamoto, Shin-ichi
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 21 p. 9524 - 9535
反应条件
1: 88 percent / K2CO3 / 1-methyl-pyrrolidin-2-one / 5 h / 120 °C 2: 60 percent / 5 N aq. NaOH / methanol / 15 h / Heating View Scheme
参考文献
Kondo; Ogawa; Shinohara; Kurimura; Tanada; Kan; Yamashita; Nakamura; Hirano; Yamamura; Mori; Tominaga; Itai
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4388 - 4397
反应条件
1: 88 percent / K2CO3 / 1-methyl-pyrrolidin-2-one / 5 h / 120 °C 2: 60 percent / 5 N aq. NaOH / methanol / 15 h / Heating View Scheme
参考文献
Kondo; Ogawa; Shinohara; Kurimura; Tanada; Kan; Yamashita; Nakamura; Hirano; Yamamura; Mori; Tominaga; Itai
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4388 - 4397
