对甲苯磺酰氧甲基膦酸二乙酯合成路线 （共 19 条）
反应条件
1: formaldehyd; phosphonic acid diethyl ester With triethylamine in toluene T=85 - 90°C; 3 h; Heating / reflux; 2: p-toluenesulfonyl chloride With triethylamine T=4 - 20°C; 14.75 h;
参考文献
Kopcho, Joseph J.; Reddy, K. Raja; Matelich, Michael C.; Ugarkar, Bheemarao G.
Patent: US2003/225277 A1, 2003 ;
Location in patent: Page 10 ;
反应条件
triethylamine in diethyl ether T=-10 - 20°C; 17 h;
参考文献
CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE LA MEDITERRANEE; K.U. LEUVEN RESEARCH and DEVELOPMENT
Patent: WO2008/56264 A2, 2008 ;
Location in patent: Page/Page column 71-72 ;
反应条件
triethylamine in diethyl ether
参考文献
Merlo, Valeria; Roberts, Stanley M.; Storer, Richard; Bethell, Richard C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 11 p. 1477 - 1482
反应条件
1: phosphonic acid diethyl ester With p-formaldehyde; triethylamine in toluene T=87°C; 3 h; Heating / reflux; 2: p-toluenesulfonyl chloride With triethylamine in toluene T=0 - 22°C; 4.5 - 6 h;
参考文献
EP1243590 A2, ;
Page 9 ;
反应条件
1: 90 percent / sodium ethoxide / ethanol 2: 80 percent / Triethylamine / diethyl ether View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 47, # 12 p. 3447 - 3463
反应条件
sodium hydride 1.) DMF, RT, 2.) DMF, RT; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 22 p. 3455 - 3463
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Woo, Seo Yeon; Kim, Ji Hyun; Moon, Mi Kyeong; Han, Se-Hee; Yeon, Seul Ki; Choi, Ji Won; Jang, Bo Ko; Song, Hyo Jung; Kang, Yong Gu; Kim, Jin Woo; Lee, Jaeick; Kim, Dong Jin; Hwang, Onyou; Park, Ki Duk
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1473 - 1487
反应条件
1: (S)-1-(6-amino-9H-purin-9-yl) propan-2-ol With Mg(O-t-Bu)2 in N,N-dimethyl-formamide T=20°C; 1 h; Inert atmosphere; 2: diethyl p-toluenesulfonyloxymethylphosphonate in N,N-dimethyl-formamide T=35°C; 20 h; Inert atmosphere;
参考文献
European Journal of Medicinal Chemistry, , vol. 63, p. 869 - 881
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Journal of the American Chemical Society, , vol. 118, # 31 p. 7420 - 7421
反应条件
1: (R)-9-[2-(hydroxy)propyl]adenine With phenyl-magnesium chloride; tert-butyl alcohol in dimethyl sulfoxide T=0 - 20°C; 0.5 h; 2: diethyl p-toluenesulfonyloxymethylphosphonate T=75°C; 3.5 h; Reagent/catalyst;
参考文献
WO2014/33688 A1, ;
Page/Page column 32 ;
