2’,3’,5’-三乙酰肌苷合成路线 （共 38 条）
反应条件
1: 95 percent / CF3SO3SiMe3 / acetonitrile / reflux, 1h; rt, 16 h 2: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile 3: hydrogen / Pd/C / 16 h / 3102.9 Torr / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 2 p. 1769 - 1770
反应条件
in water; acetonitrile Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 49, # 23 p. 4340 - 4344
反应条件
1: 90 percent / chloromethylenedimethyliminium chloride / CHCl3 / 3 h / Heating 2: methanolic NH3 / 16 h / 4 °C 3: p-TsOH, acetone / 0.75 h / 24 °C View Scheme
参考文献
Camp, David; Li, Ying; McCluskey, Adam; Moni, Roger W.; Quinn, Ronald J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 6 p. 695 - 698
反应条件
1: I2; PPh3; EtN(i-Pr)2 / toluene / 0.83 h / 95 °C 2: 141 mg / NH3 / methanol / 2 h / 0 °C 3: 100 percent / 24 h / 75 °C View Scheme
参考文献
Anglin, Justin L.; Deng, Lisheng; Yao, Yuan; Cai, Guobin; Liu, Zhen; Jiang, Hong; Cheng, Gang; Chen, Pinhong; Song, Yongcheng; Dong, Shuo
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8066 - 8074,9
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=115°C; 0.116667 h;
参考文献
Buck, Ildiko M.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 11 p. 2937 - 2942
反应条件
in N-methyl-acetamide; dichloromethane
参考文献
G. D. Searle and Co.
Patent: US4992535 A1, 1991 ;
反应条件
methanol; diethyl ether; acetone
参考文献
Bredereck
Chemische Berichte, 1947 , vol. 80, p. 401,404
Full Text Show Details
Jones; Robins
Journal of the American Chemical Society, 1963 , vol. 85, p. 193,200
Full Text Show Details
Miles
Journal of Organic Chemistry, 1961 , vol. 26, p. 4761,4762
参考文献
Bredereck
Chemische Berichte, 1947 , vol. 80, p. 401,404
Full Text Show Details
Jones; Robins
Journal of the American Chemical Society, 1963 , vol. 85, p. 193,200
Full Text Show Details
Miles
Journal of Organic Chemistry, 1961 , vol. 26, p. 4761,4762
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform; water; 1,2-dichloro-ethane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4689404 A1, 1987 ;
反应条件
1: 61 percent / SnCl4 / 1,2-dichloro-ethane / 6 h / Heating 2: 74 percent / 10 N sodium hydroxide / ethanol / Ambient temperature View Scheme
参考文献
Sugiura; Furuya; Furukawa
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3253 - 3256
