4-溴-2-氟-6-硝基苯酚合成路线 （共 13 条）
反应条件
nitrogen(IV) oxide in pentane 35 min, 0 deg C then 20 min, room temperature;
参考文献
Aymes, Daniel J.; Paris, Michel R.
Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 3-4 p. 175 - 178
反应条件
1: 49 percent / liquid nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature 2: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr 3: 2., HBr, CuBr 4: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178
反应条件
1: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr 2: 2., HBr, CuBr 3: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178
反应条件
acetic acid; sodium nitrite
参考文献
Journal of the American Chemical Society, , vol. 66, p. 1872
反应条件
1: 2., HBr, CuBr 2: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178
参考文献
Journal of the American Chemical Society, , vol. 66, p. 1872
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 65 °C 2: acetic acid; zinc / 12 h / 100 °C View Scheme
参考文献
Hameed P., Shahul; Shanbhag, Gajanan; Shinde, Vikas; Chinnapattu, Murugan; Manjrekar, Praveena; Puttur, Jayashree; Patil, Vikas; Ugarkar, Bheemarao
Synthetic Communications, 2013 , vol. 43, # 24 p. 3315 - 3321
反应条件
2: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr 4: 84 percent / 48percent HBr / 4.5 h / Heating View Scheme
参考文献
Aymes, Daniel J.; Paris, Michel R.
Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 3-4 p. 175 - 178
反应条件
2: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr View Scheme
参考文献
Aymes, Daniel J.; Paris, Michel R.
Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 3-4 p. 175 - 178
参考文献
SmithKline Beecham Corporation
Patent: US6262113 B1, 2001 ;
US 6262113 B1
