4-羟基-3-硝基苯甲腈合成路线 （共 24 条）
参考文献
Journal of the Chemical Society, , p. 103,107
参考文献
Chemische Berichte, , vol. 50, p. 1354
参考文献
Journal of the Chemical Society, , p. 642,645
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Bakunov, Stanislav A.; Bakunova, Svetlana M.; Wenzler, Tanja; Ghebru, Maedot; Werbovetz, Karl A.; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 1 p. 254 - 272
反应条件
potassium carbonate in water; acetonitrile
参考文献
RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.; RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY
Patent: EP1222183 B1, 2003 ;
参考文献
Zeegers, Petrus J.; Thompson, Malcolm J.
Magnetic Resonance in Chemistry, 1992 , vol. 30, # 6 p. 497 - 499
参考文献
Borsche
Chemische Berichte, 1917 , vol. 50, p. 1354
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=20°C; 16 h; 2: With ammonium chloride; zinc in ethanol T=20°C; 24 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; L'HEUREUX, Alexandre; HIEBERT, Sheldon; HU, Carol; LAM, Patrick Y.S.; LLOYD, John; PI, Zulan; QIAO, Jennifer X.; THIBEAULT, Carl; TORA, George O.; YANG, Wu; WANG, Yufeng; WANG, Tammy C.; BOWSHER, Michael S.; RUEL, Rejean
Patent: WO2014/22343 A1, 2014 ;
Location in patent: Paragraph 00173 ;
反应条件
1: 58.6 percent / conc. H2SO4, NaOH, potassium iodide, potassium iodate / ethanol; H2O / 1 h, reflux; overnight at room temp. 2: 25.5 percent / conc. sulfuric acid / 72 h / Ambient temperature View Scheme
参考文献
Markus; Kwon
Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 12 p. 1729 - 1734
反应条件
hydrogen in methanol; Pd on active carbon
参考文献
DuPont Pharmaceuticals Company
Patent: US6207697 B1, 2001 ;
