Boc-beta-丙氨酸合成路线 （共 48 条）
反应条件
magnesium oxide in 1,4-dioxane; water
参考文献
Journal of the Chemical Society, , p. 6130 - 6138
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 6 p. 1746 - 1749
反应条件
(i) tBu3SnN3, dioxane, (ii) /BRN= 906698/, (iii) aq. NaOH; Multistep reaction;
参考文献
Angewandte Chemie, , vol. 89, p. 570 - 572
反应条件
thionyl chloride T=-40 - 40°C;
参考文献
Stover, James S.; Shi, Jin; Jin, Wei; Vogt, Peter K.; Boger, Dale L.
Journal of the American Chemical Society, 2009 , vol. 131, p. 3342 - 3348
反应条件
acetyl chloride in ethyl acetate
参考文献
Weitman, Michal; Lerman, Keti; Nudelman, Abraham; Major, Dan Thomas; Hizi, Amnon; Herschhorn, Alon
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 447 - 467
反应条件
dicyclohexyl-carbodiimide in ethylene glycol dimethyl ether 1.) 0 deg C, 5 h, 2.) 4 deg C, overnight;
参考文献
Zhang, Mingming; Sun, Shengtong; Yu, Xudong; Cao, Xinhua; Zou, Ying; Yi, Tao
Chemical Communications, 2010 , vol. 46, # 20 p. 3553 - 3555
反应条件
dicyclohexyl-carbodiimide in ethyl acetate Ambient temperature;
参考文献
Rhee, Sung W.; Ryan, Kenneth J.; Tracy, Michael; Kelson, Andrew B.; Clizbe, Lane A.; Chang, Moon-Ho; Park, Jong-Sei; Roh, Jung-Koo; Kong, Jae-Yang; Yang, Jungick; Kim, Won-Bae; Ok, Kwang-Dae
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 9 p. 773 - 785
反应条件
1: N-tert-butoxycarbonyl-β-alanine With 4-methyl-morpholine; isobutyl chloroformate in dichloromethane T=-15°C; 0.25 h; 2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane T=-15 - 20°C; 16 h;
参考文献
Blaney, Paul; Grigg, Ronald; Rankovic, Zoran; Thornton-Pett, Mark; Xu, Juan
Tetrahedron, 2002 , vol. 58, # 9 p. 1719 - 1737
反应条件
1: N-tert-butoxycarbonyl-β-alanine With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 4 h; 2: N-methoxymethyl amine hydrochloride With triethylamine in tetrahydrofuran 2 h; Further stages.;
参考文献
Incarvito; Lam; Rhatigan; Rheingold; Jin Qin; Gavrilova; Bosnich
Journal of the Chemical Society, Dalton Transactions, 2001 , # 23 p. 3478 - 3488
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C 2: 25.5 g / CH2Cl2 / 36.25 h / -15 - 20 °C View Scheme
参考文献
Shen, Jun-Wei; Qin, Dong-Guang; Zhang, Hong-Wang; Yao, Zhu-Jun
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7479 - 7484
