1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile T=0°C; 2.5 h; 2: With ammonium hydroxide in acetonitrile T=20°C;
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel, L.; PETILLO, Peter, A.; KAUFMAN, Michael, D.
Patent: WO2010/51373 A1, 2010 ;
Location in patent: Page/Page column 103-104 ;
WO 2010/051373 A1