1: With hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 3 h; 2: With sodium carbonate in water pH=10;

palladium 10 on activated carbon; hydrogen in tetrahydrofuran; methanol T=20°C; P=3040.2 Torr; 18 h;

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C 1.2: pH 3 2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C 2.2: 20 °C 3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C 3.2: pH 10 View Scheme

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C 1.2: 20 °C 2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C 2.2: pH 10 View Scheme