1-(2-萘基)-1-戊酮合成路线 （共 17 条）
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane T=-78°C; 2.5 h; Inert atmosphere;
参考文献
Du, Biao; Yuan, Changchun; Zhang, Langzhong; Yang, Li; Liu, Bo
Tetrahedron Letters, 2013 , vol. 54, # 18 p. 2217 - 2220
反应条件
oxygen; 2,2,6,6-tetramethyl-piperidine-N-oxyl; copper(I) bromide dimethylsulfide complex; bis(3-(perfluorooctyl)butyl)-2,2'-bipyridine in chlorobenzene T=90°C; Oxidation; 3 h;
参考文献
Betzemeier, Bodo; Cavazzini, Marco; Quici, Silvio; Knochel, Paul
Tetrahedron Letters, 2000 , vol. 41, # 22 p. 4343 - 4346
反应条件
1: 1,2,3,4-tetrahydro-2-naphthoyl chloride With morpholine; diisobutylaluminium hydride in tetrahydrofuran; hexane T=0°C; 0.166667 h; Inert atmosphere; 2: n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.166667 h;
参考文献
Park, Jae Kyo; Shin, Won Kyu; An, Duk Keun
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3199 - 3203
反应条件
1: With N,N,N',N',N'',N''-hexamethylphosphoric triamide in tetrahydrofuran T=-90°C; 0.5 h; 2: With water
参考文献
Andujar Sanchez, Carmen M.; Iglesias, Ma Jose; Lopez Ortiz, Fernando
Tetrahedron Letters, 2002 , vol. 43, # 14 p. 2565 - 2568
反应条件
1: 4-bromonaphthalene-2-carbonitrile; n-butyllithium in tetrahydrofuran; hexane T=-75°C; 0.5 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran; hexane T=-75 - -60°C; 3: With hydrogenchloride; water
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
1: in toluene 2: With sulfuric acid in toluene
参考文献
Meltzer, Peter C.; Butler, David; Deschamps, Jeffrey R.; Madras, Bertha K.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1420 - 1432
反应条件
1: tetrahydrofuran / -78 °C 2: MnO2 / CH2Cl2 View Scheme
参考文献
Wipf, Peter; Aslan, Diana C.; Southwick, Eileen C.; Lazo, John S.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 3 p. 313 - 317
反应条件
aluminium trichloride; nitrobenzene T=-5°C;
参考文献
Buu-Hoi; Cagniant
Bulletin de la Societe Chimique de France, 1945 , vol. <5> 12, p. 307,311
参考文献
Koelbel
Brennstoff-Chemie, 1949 , vol. 30, p. 73,75
反应条件
1: tetrahydrofuran / 16 h / 20 °C 2: AgNTf2; {1,3-bis[2,6-di(propan-2-yl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene}AuCl / dichloromethane / 2 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Lauterbach, Tobias; Arndt, Sebastian; Rudolph, Matthias; Rominger, Frank; Hashmi, A. Stephen K.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 9 p. 1755 - 1761
