2-(3,4-二甲氧基苯基)-7-羟基苯并吡喃-4-酮合成路线 （共 10 条）
反应条件
hydrogenchloride; lithium hydroxide; sulfuric acid in tetrahydrofuran; acetic acid
参考文献
Buchholz, Herwig; Perruchon, Sophie
Patent: US2004/59100 A1, 2004 ;
反应条件
1: saturated aq. potassium carbonate / benzene / 0.33 h / 60 °C 2: tetrabutylammonium hydrogen sulfate / benzene; H2O / 3 h / 60 °C 3: conc. H2SO4 / 4 h / 0 °C View Scheme
参考文献
Verma, Alok K.; Singh, Himanshu; Satyanarayana, Mavurapu; Srivastava, Swayam P.; Tiwari, Priti; Singh, Amar B.; Dwivedi, Anil K.; Singh, Shio K.; Srivastava, Mukesh; Nath, Chandishwar; Raghubir, Ram; Srivastava, Arvind K.; Pratap, Ram
Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4551 - 4567
反应条件
1: saturated aq. potassium carbonate / benzene / 0.33 h / 60 °C 2: tetrabutylammonium hydrogen sulfate / benzene; H2O / 3 h / 60 °C 3: conc. H2SO4 / 4 h / 0 °C View Scheme
参考文献
Saxena, Shabnam; Makrandi, J. K.; Grover, S. K.
Synthesis, 1985 , # 6/7 p. 697
反应条件
sulfuric acid T=0°C; 4 h; Yield given;
参考文献
Verma, Alok K.; Singh, Himanshu; Satyanarayana, Mavurapu; Srivastava, Swayam P.; Tiwari, Priti; Singh, Amar B.; Dwivedi, Anil K.; Singh, Shio K.; Srivastava, Mukesh; Nath, Chandishwar; Raghubir, Ram; Srivastava, Arvind K.; Pratap, Ram
Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4551 - 4567
反应条件
1.1: sodium hydroxide / 3 h 1.2: 3 h / 20 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -30 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere 3.1: Dowex-H / isopropyl alcohol / Reflux View Scheme
参考文献
Verma, Alok K.; Singh, Himanshu; Satyanarayana, Mavurapu; Srivastava, Swayam P.; Tiwari, Priti; Singh, Amar B.; Dwivedi, Anil K.; Singh, Shio K.; Srivastava, Mukesh; Nath, Chandishwar; Raghubir, Ram; Srivastava, Arvind K.; Pratap, Ram
Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4551 - 4567
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -30 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: Dowex-H / isopropyl alcohol / Reflux View Scheme
参考文献
Verma, Alok K.; Singh, Himanshu; Satyanarayana, Mavurapu; Srivastava, Swayam P.; Tiwari, Priti; Singh, Amar B.; Dwivedi, Anil K.; Singh, Shio K.; Srivastava, Mukesh; Nath, Chandishwar; Raghubir, Ram; Srivastava, Arvind K.; Pratap, Ram
Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4551 - 4567
反应条件
sodium acetate; acetic acid Erwaermen des Reaktionsprodukts mit methanol. Kalilauge;
参考文献
Baker
Journal of the Chemical Society, 1933 , p. 1381,1387
参考文献
Pillon
Bulletin de la Societe Chimique de France, 1954 , p. 9,21
参考文献
Baker
Journal of the Chemical Society, 1933 , p. 1381,1387
参考文献
Gupta; Dhiman; Ahmed
Pharmazie, 1985 , vol. 40, # 4 p. 273 - 274
