2,6-二溴-4-氟苯酚合成路线 （共 13 条）
反应条件
bromine in acetic acid T=20°C;
参考文献
GALENEA CORPORATION; ELDER, Amy; HARRIMAN, Geraldine; LEIT, Silvana; LI, Jie; SARD, Howard; ZHANG, Yiliang; WILSON, Doug
Patent: WO2011/19738 A1, 2011 ;
Location in patent: Page/Page column 143 ;
WO 2011/019738 A1
反应条件
1: sulfuric acid; sodium nitrite; phosphoric acid / Erhitzen des Reaktionsgemisches mit Kupfer(II)-sulfat und wss. Schwefelsaeure auf 140grad 2: water; bromine View Scheme
参考文献
Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
反应条件
bromine; potassium carbonate 1.) CS2, ether, r.t., 1 d; 2.) reflux, 3 h; 3.) acetone; Yield given. Multistep reaction;
参考文献
Canadian Journal of Chemistry, , vol. 62, p. 1592 - 1597
参考文献
Journal of the American Chemical Society, , vol. 66, p. 2080
参考文献
Journal of the Chemical Society, , p. 1085
反应条件
tetrakis(triphenylphosphine) palladium(0); iodine; magnesium 1.) THF, reflux, 30 min, 2.) reflux, 5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Synthesis, , # 9 p. 827 - 833
反应条件
potassium carbonate in acetone 6 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/104754 A1, 2008 ;
Location in patent: Page/Page column 174 ;
WO 2008/104754 A1
反应条件
CH3I; potassium carbonate in acetone
参考文献
Brown, William; Walpole, Christopher
Patent: US2003/36552 A1, 2003 ;
参考文献
Schering Aktiengesellschaft
Patent: US5130119 A1, 1992 ;
参考文献
Finger et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97
