4-甲基吡咯-2-羧酸甲酯合成路线 （共 24 条）
反应条件
lithium in methanol Heating;
参考文献
Xiao, Dong; Schreier, Jeffrey A.; Cook, James H.; Seybold, Paul G.; Ketcha, Daniel M.
Tetrahedron Letters, 1996 , vol. 37, # 10 p. 1523 - 1526
反应条件
1: With thionyl chloride in methanol T=20°C; 24 h; 2: With sodium methylate T=20°C; 1.5 h;
参考文献
Arakawa, Yasushi; Yagi, Naomi; Arakawa, Yukimi; Tanaka, Ken-Ichi; Yoshifuji, Shigeyuki
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 2 p. 167 - 176
反应条件
2-(tert-butyl)-1,1,3,3-tetramethylguanidine in tetrahydrofuran; tert-butyl alcohol 0.333333 h; Ambient temperature;
参考文献
Barton, Derek H. R.; Zard, Samir Z.
Journal of the Chemical Society, Chemical Communications, 1985 , # 16 p. 1098 - 1100
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene 12 h; Reflux;
参考文献
Arakawa, Yasushi; Yagi, Naomi; Arakawa, Yukimi; Tanaka, Ken-Ichi; Yoshifuji, Shigeyuki
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 2 p. 167 - 176
反应条件
sodium methylate in methanol
参考文献
Cornforth, John; Ming-hui, Du
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1459 - 1462
反应条件
copper diacetate; N-ethyl-N,N-diisopropylamine in methoxybenzene T=130°C; 12 h;
参考文献
Tetrahedron Letters, , vol. 46, # 15 p. 2563 - 2566
反应条件
sodium hydride in dimethyl sulfoxide; paraffin 3 h;
参考文献
Cornforth, John; Ming-hui, Du
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1459 - 1462
反应条件
1: 98 percent / t-BuNH2*BH3, AlCl3 2: 69 percent / BF3Et2O / 48 h 3: Br2, NaOH 4: H2SO4 5: 94 percent / Li / methanol / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 10 p. 1523 - 1526
反应条件
1: 69 percent / BF3Et2O / 48 h 2: Br2, NaOH 3: H2SO4 4: 94 percent / Li / methanol / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 10 p. 1523 - 1526
反应条件
1: 93 percent / 4-dimethylaminopyridine / acetonitrile / 13 h / 20 °C 2: TBAF / tetrahydrofuran / 8 h / 60 °C 3: Cu(OAc)2; i-Pr2NEt / methoxybenzene / 12 h / 130 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 15 p. 2563 - 2566
