4,4'-二氟二苯甲酮合成路线 （共 115 条）
反应条件
1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 2 h, b) 0 deg C, 10 min 2: 100 percent / p-toluenesulfonic acid / toluene / 12 h / Heating 3: 100 percent / DIBAL / CH2Cl2 / 2 h / 0 °C View Scheme
参考文献
Baader, E.; Bartmann, W.; Beck, G.; Bergmann, A.; Jendralla, H.; et al.
Tetrahedron Letters, 1988 , vol. 29, # 8 p. 929 - 930
反应条件
1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 2 h, b) 0 deg C, 10 min 2: 100 percent / p-toluenesulfonic acid / toluene / 12 h / Heating View Scheme
参考文献
Baader, E.; Bartmann, W.; Beck, G.; Bergmann, A.; Jendralla, H.; et al.
Tetrahedron Letters, 1988 , vol. 29, # 8 p. 929 - 930
反应条件
in water 30 h; Reflux;
参考文献
Shirinian, Valerii Z.; Shimkin, Alexey A.; Lonshakov, Dmitry V.; Mailyan, Artur K.; Lvov, Andrey G.; Krayushkin, Michail M.
Synthesis, 2012 , vol. 44, # 4 p. 527 - 531
反应条件
1: NH2OH*HCl, NaOH / ethanol; H2O / 1 h / Heating
2: Et3N / tetrahydrofuran / 1 h / Ambient temperature
3: 93 percent / SbCl5, AgSbF6 / 1,2-dichloro-ethane / 3 h / Heating
View Scheme
参考文献
Dunlop; Gardner
Journal of the American Chemical Society, 1933 , vol. 55, p. 1665
反应条件
in various solvent(s)
T=140°C; 40 h;
参考文献
Spange, Stefan; El-Sayed, Mohamed; Mueller, Hardy; Rheinwald, Gerd; Lang, Heinrich; Poppitz, Wolfgang
European Journal of Organic Chemistry, 2002 , # 24 p. 4159 - 4168
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1535922 A1, 2005 ;
Location in patent: Page/Page column 47 ;
参考文献
MERCK SHARP and DOHME CORP.; DANG, Qun; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia
Patent: WO2013/43621 A1, 2013 ;
Location in patent: Page/Page column 42-43 ;
反应条件
in dimethyl sulfoxide
T=140°C; 40 h;
参考文献
Spange, Stefan; El-Sayed, Mohamed; Mueller, Hardy; Rheinwald, Gerd; Lang, Heinrich; Poppitz, Wolfgang
European Journal of Organic Chemistry, 2002 , # 24 p. 4159 - 4168
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
IMPERIAL CHEMICAL INDUSTRIES PLC
Patent: EP131684 B1, 1992 ;
反应条件
in N-methyl-acetamide; dimethyl sulfoxide
参考文献
Akzo N.V.
Patent: US5238939 A1, 1993 ;
