2-(4-氟苯基)苯乙酮合成路线 （共 22 条）
反应条件
Ni(PCy3)2Cl2; sodium t-butanolate in N,N-dimethyl-formamide; toluene T=100°C; Suzuki-Miyaura coupling; 0.666667 h; Inert atmosphere;
参考文献
Huang, Kun; Li, Gang; Huang, Wei-Ping; Yu, Da-Gang; Shi, Zhang-Jie
Chemical Communications, 2011 , vol. 47, # 25 p. 7224 - 7226
反应条件
phosphorus trichoride; aluminium trichloride in benzene
参考文献
Denney, Donald B.; Denney, Dorothy Z.; Pastor, Stephen D.
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 22, p. 191 - 198
反应条件
1: phosphoric acid diethyl ester 4-fluoro-benzyl ester With manganese in tetrahydrofuran T=20°C; 8 h; 2: benzoyl chloride in tetrahydrofuran T=20°C; 1 h;
参考文献
Suh, YoungSung; Lee, Jun-Sik; Kim, Seoung-Hoi; Rieke, Reuben D.
Journal of Organometallic Chemistry, 2003 , vol. 684, # 1-2 p. 20 - 36
反应条件
sodium hexamethyldisilazane in tetrahydrofuran; N,N-dimethyl-formamide T=-10°C; Claisen condensation; 3.5 h; Inert atmosphere;
参考文献
Wu, Guiyong; Yin, Weiyu; Shen, Hong C.; Huang, Yong
Green Chemistry, 2012 , vol. 14, # 3 p. 580 - 585
反应条件
tris(trifluoroacetoxy)-λ3-iodane in tetrachloromethane T=23°C; 3 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 62, # 10 p. 3182 - 3186
反应条件
water; palladium diacetate; potassium hydrogencarbonate; tri-cyclo-hexyl-phosphine T=100°C; Suzuki coupling; P=7500.75 Torr; 20 h; Inert atmosphere;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 5 p. 788 - 792
反应条件
1: 59 percent / CH2Cl2 / 40 - 42 °C 2: 57 percent / KOH / ethanol / Heating View Scheme
参考文献
Synlett, , # 14 p. 2189 - 2192
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / Inert atmosphere; Cooling 1.2: Inert atmosphere; Cooling 2.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / -45 °C / Inert atmosphere 2.2: -45 - 20 °C / Inert atmosphere View Scheme
参考文献
Synthesis, , # 22 art. no. F71511SS, p. 3615 - 3626
反应条件
1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 2: Ni(PCy3)2Cl2; sodium t-butanolate / N,N-dimethyl-formamide; toluene / 0.67 h / 100 °C / Inert atmosphere View Scheme
参考文献
Chemical Communications, , vol. 47, # 25 p. 7224 - 7226
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere 1.2: 3 h / -78 - -30 °C / Inert atmosphere 2.1: lithium diisopropyl amide / tetrahydrofuran / Inert atmosphere; Cooling 2.2: Inert atmosphere; Cooling 3.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / -45 °C / Inert atmosphere 3.2: -45 - 20 °C / Inert atmosphere View Scheme
参考文献
Synthesis, , # 22 art. no. F71511SS, p. 3615 - 3626
