2-(三苯甲游基硫代)乙酸合成路线 （共 17 条）
参考文献
Ding, Rui; He, Yong; Xu, Jingli; Liu, Hang; Wang, Xiao; Feng, Man; Qi, Chuanmin; Zhang, Junbo; Peng, Cheng
Medicinal Chemistry Research, 2012 , vol. 21, # 4 p. 523 - 530
反应条件
1: With potassium hydroxide in methanol 2: With hydrogenchloride in ethanol; water pH=6;
参考文献
Liu, Show-Wen; Lin, Cheng-Hsien; Lin, Tsyh-Lang; Hsu, Cheng-Fang
Patent: US2011/40123 A1, 2011 ;
Location in patent: Page/Page column 2; Sheet 4 ;
反应条件
1: With sodium hydroxide; water in 1,4-dioxane 2 h; Heating / reflux; 2: With water; citric acid pH=2 - 4;
参考文献
ABSOLUTE SCIENCE, INC.
Patent: WO2009/45761 A1, 2009 ;
Location in patent: Page/Page column 65 ;
WO 2009/045761 A1
反应条件
trifluoroacetic acid in chloroform T=20°C; 3 h;
参考文献
Kalin, Jay H.; Zhang, Hankun; Gaudrel-Grosay, Sophie; Vistoli, Giulio; Kozikowski, Alan P.
ChemMedChem, 2012 , vol. 7, # 3 p. 425 - 439
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
Smeenk, Linde E. J.; Dailly, Nicolas; Hiemstra, Henk; Van Maarseveen, Jan H.; Timmerman, Peter
Organic Letters, 2012 , vol. 14, # 5 p. 1194 - 1197
反应条件
sodium hydroxide in methanol T=75°C; 4 h;
参考文献
Gal, Julien Le; Michaud, Sandra; Gressier, Marie; Coulais, Yvon; Benoist, Eric
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 2904 - 2909
反应条件
sulfuric acid T=70°C; 12 h;
参考文献
BRACCO IMAGING S.P.A.
Patent: WO2007/109475 A2, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 38 percent / Et3N / CH2Cl2 / 4 h / 20 °C 2: 97 percent / NaOH / methanol; tetrahydrofuran; H2O / 1 h / 20 °C View Scheme
参考文献
Woll, Matthew G.; Hadley, Erik B.; Mecozzi, Sandro; Gellman, Samuel H.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15932 - 15933
反应条件
trifluoroacetic acid
参考文献
Yamada, Koichiro; Matsuki, Kenji; Omori, Kenji; Kikkawa, Kohei
Patent: US2004/142930 A1, 2004 ;
US 20040142930 A1
反应条件
water; sodium thiosulfate anschliessend erhitzen mit Tritylchlorid und konz. wss. HCl;
参考文献
Henkel and Cie.
Patent: DE814596 , 1948 ;
DRP/DRBP Org.Chem.
