5,6,7,8-四氢喹唑啉-2,4(1H,3H)-二酮合成路线 （共 23 条）
反应条件
1: 72 percent / Ca(OH)2 / ethanol; H2O / 72 h / 40 °C 2: 2N H2SO4 / ethanol; H2O / 48 h / 70 °C / pH=2 View Scheme
参考文献
Tetrahedron, , vol. 40, # 17 p. 3313 - 3320
反应条件
1.1: sodium hydride / tetrahydrofuran / 1 h / |Reflux 1.2: 2 h / |Reflux 2.1: 175 - 185 °C 2.2: 2 h / 70 °C / pH 13 - 14 View Scheme
参考文献
Zhang, Zhiyuan; Wallace, Michael B.; Feng, Jun; Stafford, Jeffrey A.; Skene, Robert J.; Shi, Lihong; Lee, Bumsup; Aertgeerts, Kathleen; Jennings, Andy; Xu, Rongda; Kassel, Daniel B.; Kaldor, Stephen W.; Navre, Marc; Webb, David R.; Gwaltney, Stephen L.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 2 p. 510 - 524
反应条件
1: phosphorous oxychloride
2: 75 percent / aqu. ammonia / ethanol / 100 °C
3: 35 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: phosphorous oxychloride
2: 75 percent / aqu. ammonia / ethanol / 100 °C
3: 58 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: phosphorous oxychloride
2: 75 percent / aqu. ammonia / ethanol / 100 °C
3: 85 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: phosphorous oxychloride
2: 83 percent / tetrahydrofuran; H2O / Ambient temperature
3: 3-methyl-butan-1-ol / 4 h / Heating
4: 10 percent hydrochloric acid / 1 h / 100 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: phosphorous oxychloride
2: 59 percent / tetrahydrofuran; H2O / Ambient temperature
3: 3-methyl-butan-1-ol / 4 h / Heating
4: 10 percent hydrochloric acid / 1 h / 100 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: phosphorous oxychloride
2: 49 percent / tetrahydrofuran; H2O / Ambient temperature
3: 3-methyl-butan-1-ol / 4 h / Heating
4: 10 percent hydrochloric acid / 1 h / 100 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: phosphorous oxychloride
2: 47 percent / tetrahydrofuran; H2O / Ambient temperature
3: 3-methyl-butan-1-ol / 4 h / Heating
4: 10 percent hydrochloric acid / 1 h / 100 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
