3-氟-4-甲氧基苯甲醛合成路线 （共 31 条）
反应条件
1: concentrated sulfuric acid; nitric acid / -10 °C 2: potassium permanganate; water 3: hydrogen chloride 4: platinum; methanol / Hydrogenation View Scheme
参考文献
English; Mead; Niemann
Journal of the American Chemical Society, 1940 , vol. 62, p. 350,353
反应条件
1.1: boron tribromide / dichloromethane / 24 h / |Cooling with ice 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / |Cooling with ice 2.2: 24 h / |Reflux View Scheme
参考文献
Ottana, Rosaria; Maccari, Rosanna; Mortier, Jeremie; Caselli, Anna; Amuso, Simona; Camici, Guido; Rotondo, Archimede; Wolber, Gerhard; Paoli, Paolo
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 112 - 127
参考文献
Pharmacia Corporation
Patent: US6531494 B1, 2003 ;
反应条件
pyridine; malonic acid; palladium monocarbide in water; acetic acid
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6034239 A1, 2000 ;
US 6034239 A
反应条件
1: With triethylammonium formate
T=100°C; 5 h;
2: With hydrogenchloride in water
T=20°C; pH=1;
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.
Patent: US2012/225876 A1, 2012 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1: With piperidine in pyridine
T=120°C; Aldol Condensation; 7 h;
2: With hydrogen; 5 palladium over charcoal in water; acetic acid
T=20°C; 2 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1199304 A1, 2002 ;
Location in patent: Referential example 8 ;
EP 1199304 A1
参考文献
Mamaew
Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 1290,1293; engl. Ausg. S. 1376, 1378
反应条件
ammonium acetate; ethanol
参考文献
Mamaew
Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 1290,1293; engl. Ausg. S. 1376, 1378
参考文献
Tatsuzaki, Jin; Bastow, Kenneth F.; Nakagawa-Goto, Kyoko; Nakamura, Seiko; Itokawa, Hideji; Lee, Kuo-Hsiung
Journal of Natural Products, 2006 , vol. 69, # 10 p. 1445 - 1449
反应条件
1.1: triethylammonium formate / 5 h / 100 °C
1.2: 20 °C / pH 1
2.1: thionyl chloride / toluene / 1 h / 90 °C
2.2: 1 h / Cooling with ice
2.3: 1 h / Cooling with ice
3.1: boron tribromide / dichloromethane / 7 h / 20 °C / Cooling with ice
View Scheme
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.
Patent: US2012/225876 A1, 2012 ;
