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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
4-氟苯基溴化镁
合成路线
（共 243 条）
19070-16-7
氯[3-(二甲基氨基)丙基]镁
+
82104-74-3
5-氰基苯酞
+
352-13-6
4-氟苯基溴化镁
→
反应条件
103146-25-4
4-(4-二甲胺基-1-对氟苯基-1-羟基丁基)-3-(羟甲基)苯腈
反应条件
1: 5-cyano-isobenzofuran-1-one; (4-fluoro-phenyl)-magnesium bromide With diethylene glycol dimethyl ether; tetrabutyl-ammonium chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: 3-(N,N-dimethylamino)-propylmagnesium chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Zong, Hua; Huang, Huayin; Liu, Junfeng; Bian, Guangling; Song, Ling
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4645 - 4652
1412967-16-8
+
352-13-6
4-氟苯基溴化镁
→
反应条件
163222-32-0
(3R,4S)-1-(4-氟苯基)-3-[(3S)-3-(4-氟苯基)-3-羟基丙基]-4-[4-(苯甲氧基)苯基]-2-氮杂环丁酮
反应条件
1: (4-fluoro-phenyl)-magnesium bromide With (R)-2,2'-dihydroxy-1,1'-binaphthyl; titanium(IV) isopropylate in tetrahydrofuran; diethyl ether T=0 - 25°C; 1.5 h; 2: 3-[(2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3- yl]propanal in tetrahydrofuran; diethyl ether T=-20 - 25°C; 3: With hydrogenchloride; water in tetrahydrofuran; diethyl ether T=0°C;
参考文献
PHARMATHEN S.A.; KOFTIS, Theocharis V.; ANDREOU, Thanos; GIOTI, Efthimia; ZITROU, Asteria
Patent: WO2012/155932 A1, 2012 ;
Location in patent: Page/Page column 11 ;
352-13-6
4-氟苯基溴化镁
→
反应条件
1679-64-7
对苯二甲酸单甲酯
反应条件
1: tetrahydrofuran / 2 h / 0 °C 2: 96 percent / PCC; Celite / CH2Cl2 / 20 °C 3: 83 percent / dimethylformamide / 48 h / 150 °C 4: 89 percent / KOH / ethanol; H2O / 72 h / Heating 5: diethyl ether 6: Irradiation View Scheme
参考文献
Xia, Wujiong; Scheffer, John R.; Botoshansky, Mark; Kaftory, Menahem
Organic Letters, 2005 , vol. 7, # 7 p. 1315 - 1318
19070-16-7
氯[3-(二甲基氨基)丙基]镁
+
82104-74-3
5-氰基苯酞
+
352-13-6
4-氟苯基溴化镁
→
反应条件
103146-26-5
4-[4-(二甲氨基)-1-(4-氟苯基)-1-羟丁基]-3-羟甲基苯腈氢溴酸盐
反应条件
1: 5-cyano-isobenzofuran-1-one; (4-fluoro-phenyl)-magnesium bromide in tetrahydrofuran; dichloromethane T=-5 - 5°C; 0.5 h; 2: 3-(N,N-dimethylamino)-propylmagnesium chloride in tetrahydrofuran; dichloromethane; toluene T=-5 - 5°C;
参考文献
Vedantham, Ravindra; Chinta, Raveendra Reddy; Vetukuri, Venkata Naga Kali Vara Prasada Raju; Boini, Ambaiah; Sundaraneedi, Veera Madhavi; Medisetti, Rama Krishna Venkata; Manudhane, Kushal Surajmal
Patent: US2010/87664 A1, 2010 ;
Location in patent: Page/Page column 4 ;
4538-50-5
环氧乙烷-2-羧酸甲酯
+
352-13-6
4-氟苯基溴化镁
→
反应条件
124980-98-9
(r)-3-(4-氟苯基)-2-羟基丙酸甲酯
反应条件
CuBr-Me2S in tetrahydrofuran T=-35°C; 1 h;
参考文献
Shie, Jiun-Jie; Fang, Jim-Min; Kuo, Tun-Hsun; Kuo, Chih-Jung; Liang, Po-Huang; Huang, Hung-Jyun; Wu, Yin-Ta; Jan, Jia-Tsrong; Cheng, Yih-Shyun E.; Wong, Chi-Huey
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 17 p. 5240 - 5252
108-94-1
环己酮
+
352-13-6
4-氟苯基溴化镁
→
反应条件
1496-36-2
反应条件
暂无反应条件数据
参考文献
Thurkauf, Andrew; Costa, Brian de; Yamaguchi, Shun-ichi; Mattson, Mariena V.; Jacobson, Arthur E.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1452 - 1458
3612-20-2
N-苄基哌啶酮
+
352-13-6
4-氟苯基溴化镁
→
反应条件
163631-02-5
1-苄基-4-(4-氟苯基)哌啶-4-醇
反应条件
in tetrahydrofuran; hexane; ethyl acetate
参考文献
Synaptic Pharmaceutical Corporation
Patent: US6159990 A1, 2000 ;
US 6159990 A
455-18-5
对三氟甲基苯腈
+
352-13-6
4-氟苯基溴化镁
→
反应条件
16574-52-0
4-氟-4'-(三氟甲基)二苯甲酮
反应条件
1: in tetrahydrofuran T=67°C; 6 h; Inert atmosphere; 2: With sulfuric acid; water in tetrahydrofuran Inert atmosphere;
参考文献
Muehlhausen, Ute; Ermert, Johannes; Coenen, Heinz H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 1 p. 13 - 22
542-18-7
氯代环己烷
+
352-13-6
4-氟苯基溴化镁
→
反应条件
1717-84-6
反应条件
anhydrous iron chloride; Ipr.HCl in tetrahydrofuran T=0 - 40°C; 1.66667 h;
参考文献
Ghorai, Sujit K.; Jin, Masayoshi; Hatakeyama, Takuji; Nakamura, Masaharu
Organic Letters, 2012 , vol. 14, # 4 p. 1066 - 1069
108-85-0
+
352-13-6
4-氟苯基溴化镁
→
反应条件
1717-84-6
反应条件
1: (4-fluoro-phenyl)-magnesium bromide With vanadium(III) chloride in tetrahydrofuran T=20°C; 0.333333 h; 2: 1-bromocyclohexane in tetrahydrofuran 1 h; Reflux;
参考文献
Yasuda, Shigeo; Yorimitsu, Hideki; Oshima, Koichiro
Bulletin of the Chemical Society of Japan, 2008 , vol. 81, # 2 p. 287 - 290
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