1-(3-氨基丙基)哌啶合成路线 （共 21 条）
反应条件
perchloric acid T=25°C; E(a), ΔS(excit.); Rate constantThermodynamic data;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 61, # 8.2 p. 1841 - 1856,1700 - 1713
反应条件
1: With triethylamine in dichloromethane 2: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 3: With sodium hydroxide; water in tetrahydrofuran T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/138033 A1, 2007 ;
Location in patent: Page/Page column 31 ;
反应条件
1: 62 percent / diethyl ether / 12 h / Heating 2: 72 percent / LiAlH4 / diethyl ether / 10 h / Heating View Scheme
参考文献
Arendaruk, A. P.; Abramova, N. A.; Skoldinov, A. P.; Kharkevich, D. A.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 464 - 467
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 802 - 806
参考文献
Terentew; Terentewa
Zhurnal Obshchei Khimii, 1942 , vol. 12, p. 415
Chem.Abstr., 1943 , p. 3095
反应条件
1: Heating 2: LiAlH4 / diethyl ether / 3 h View Scheme
参考文献
Badger; Schwartz; Picker; Dorman; Bradley; Cheeseman; DiMartino; Hanna; Mirabelli
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2963 - 2970
反应条件
in benzene
1 h; Ambient temperature;
参考文献
Nakashima; Kawashima; Amanuma; Sota; Tanaka; Kameyama
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 11 p. 4271 - 4280
反应条件
triethylamine in dichloromethane
T=20°C; 2 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/5503 A1, 2007 ;
Location in patent: Page/Page column 33 ;
WO 2007/005503 A1
参考文献
Schmid et al.
Helvetica Chimica Acta, 1956 , vol. 39, p. 607,616
反应条件
2: ethanol; NH3
View Scheme
参考文献
Mosher; Whitmore
Journal of the American Chemical Society, 1945 , vol. 67, p. 662
参考文献
Mosher; Whitmore
Journal of the American Chemical Society, 1945 , vol. 67, p. 662
