2-氯-N-(2-氯乙基)-N-乙胺盐酸盐合成路线 （共 3 条）
反应条件
thionyl chloride in chloroform 1 h; Heating;
参考文献
Hansen, T. K.; Joergensen, T.; Jensen, F.; Thygesen, P. H.; Christiansen, K.; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1359 - 1366
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
McDonald, Joseph J.; Kassab, Darren J.; Massa, Mark A.; Grapperhaus, Margaret L.; Schmidt, Michelle A.; Rico, Joseph G.; Mullins, Patrick B.; Brown, David L.
Patent: US2005/209278 A1, 2005 ;
US 20050209278 A1
反应条件
1: 1,3-dihydro-indol-2-one With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.5 h;
2: 1,5-Dichloro-3-ethyl-3-azapentane, Hydrochloride in tetrahydrofuran
T=-78 - 20°C; 18 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/69256 A1, 2004 ;
Location in patent: Page/Page column 47-48 ;
WO 2004/069256 A1
