1-(3-吡啶)-1,3-丁二酮合成路线 （共 15 条）
反应条件
diethyl ether; sodium methylate
参考文献
NOVARTIS AG; BEATTIE, David; BRUCE, Ian; COLSON, Anny-Odile; CULSHAW, Andrew James; SHARP, Thomas
Patent: WO2011/95450 A1, 2011 ;
Location in patent: Page/Page column 98 ;
WO 2011/095450 A1
反应条件
1: 3-acetyl-pyridine With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.166667 h; 2: methyl acetate in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; FRIEMAN, Bryan, A.; KALLEL, Edward, Adam; MILLER, Mark, Thomas; UY, Johnny; ZHOU, Jinglan
Patent: WO2013/109521 A1, 2013 ;
Location in patent: Paragraph 00192; 00193 ;
反应条件
sodium methylate in tetrahydrofuran T=20°C; 72 h; Inert atmosphere;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; FRIEMAN, Bryan, A.; KALLEL, Edward, Adam; MILLER, Mark, Thomas; UY, Johnny; ZHOU, Jinglan
Patent: WO2013/109521 A1, 2013 ;
Location in patent: Paragraph 00192; 00195 ;
反应条件
hydrogenchloride in N,N-dimethyl-formamide 4 h; Ambient temperature;
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; cataCXium®A; caesium carbonate T=60°C; P=2250.23 Torr; 36 h; GloveboxInert atmosphereAutoclave;
参考文献
Schranck, Johannes; Tlili, Anis; Alsabeh, Pamela G.; Neumann, Helfried; Stradiotto, Mark; Beller, Matthias
Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12624 - 12628
反应条件
hydrogenchloride in water T=80°C; 1 h;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Lindhardt, Anders T.; Skrydstrup, Troels
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17687 - 17691
反应条件
potassium tert-butylate in tetrahydrofuran 24 h;
参考文献
Walker, Michael A.; Johnson, Timothy; Ma, Zhuping; Banville, Jacques; Remillard, Roger; Kim, Oak; Zhang, Yunhui; Staab, Andrew; Wong, Henry; Torri, Albert; Samanta, Himadri; Lin, Zeyu; Deminie, Carol; Terry, Brian; Krystal, Mark; Meanwell, Nicholas
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2920 - 2924
反应条件
1: dimethylformamide / 1 h / Ambient temperature 2: 87 percent / 2.) dil. HCl / dimethylformamide / 4 h / Ambient temperature View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
1.1: dichloro(cycloocta-1,5-diene)palladium(II); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; magnesium chloride; triethylamine / 1,4-dioxane / 80 °C / |Glovebox; |Inert atmosphere 1.2: 80 °C / |Glovebox; |Inert atmosphere 1.3: 18 h / 80 °C 2.1: hydrogenchloride / water / 1 h / 80 °C View Scheme
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Lindhardt, Anders T.; Skrydstrup, Troels
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17687 - 17691
反应条件
potassium hydroxide; hydrazine hydrate; 1,2-bis-(2-hydroxyethoxy)-ethane T=190°C;
参考文献
Frank; Weatherbee
Journal of the American Chemical Society, 1948 , vol. 70, p. 3482
