1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux 1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice 2.1: methanesulfonic acid / toluene / 4 h / Reflux View Scheme
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Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
1: 1-Phenylmethyl-piperidin-4-one With sodium hydride in tetrahydrofuran T=-5°C; 1 h; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; 4 h; 3: With ammonium chloride in tetrahydrofuran; water
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SCHERING CORPORATION
Patent: WO2008/130584 A1, 2008 ;
Location in patent: Page/Page column 161 ;
WO 2008/130584 A1
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Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1459 - 1462
1: With magnesium sulfate in N,N-dimethyl acetamide T=55°C; 48 h; 2: With sulfuric acid; water T=100°C; 0.166667 h; 3: With sodium hydroxide in water T=0°C; pH=9;
参考文献
SOLVAY PHARMACEUTICALS GMBH
Patent: WO2007/88181 A1, 2007 ;
Location in patent: Page/Page column 67 ;
WO 2007/088181 A1
