1-(噻唑-2-基)环丁醇合成路线 (共 2 条)
反应条件
1: 1,3-thiazole With n-butyllithium in tetrahydrofuran T=-78°C; 0.25 h; 2: cyclobutyl ketone in tetrahydrofuran 0.166667 h;
参考文献
ABBOTT LABORATORIES
Patent: US2011/281842 A1, 2011 ;
Location in patent: Page/Page column 30 ;
反应条件
n-butyllithium in hexane
参考文献
Freisen, Richard; Ducharme, Yves; Cote, Bernard; Blouin, Marc; Martins, Evelyn; Guay, Daniel; Hamel, Pierre; Girard, Mario; Frenette, Richard; Laliberte, Sebastien
Patent: US2002/13347 A1, 2002 ;
US 20020013347 A1