(R)-(+)-N-乙酰基-甲基苄胺合成路线 （共 87 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 1.2: 18 h / 20 °C 2.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere 3.1: triethylamine; 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 11 p. 5314 - 5327
反应条件
1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere 2: triethylamine; 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 11 p. 5314 - 5327
反应条件
1.1: N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; (R)-TRIP-BINOL / benzene / 20 h / 20 - 50 °C / |Molecular sieve; |Inert atmosphere 2.1: trichloroisocyanuric acid; camphor-10-sulfonic acid / water; acetonitrile / 14 h / 20 °C / |Inert atmosphere 2.2: 22 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 32 p. 11740 - 11743
反应条件
1: 1-amino-1-phenylethane With N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; 2: C10H14N2O5S2F6 With N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Further stages.;
参考文献
Tetrahedron, , vol. 63, # 28 p. 6415 - 6422
反应条件
in toluene T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 25 p. 3314 - 3317
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 48 h;
参考文献
Satyanarayana, Tummanapalli; Kagan, Henri B.
Chemistry - A European Journal, 2006 , vol. 12, # 22 p. 5785 - 5789
反应条件
in chloroform T=23°C; 1 h;
参考文献
Journal of the American Chemical Society, , vol. 134, # 50 p. 20318 - 20321
反应条件
in dichloromethane T=-10°C; 10 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , vol. 2, # 2 p. 257 - 274
反应条件
in chloroform-d1 T=-20 - 5°C; 14 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , vol. 2, # 2 p. 257 - 274
反应条件
in dichloromethane T=-78°C; Acetylation; Product distribution; Further Variations:SolventsTemperatures;
参考文献
Chemical Communications, , # 2 p. 119 - 120
