6-氨基-己酸乙酯盐酸盐合成路线 （共 12 条）
反应条件
thionyl chloride 18 h; Ambient temperature;
参考文献
Ryabinin, Vladimir A.; Sinyakov, Alexander N.; De Soultrait, Vaea Richard; Caumont, Anne; Parissi, Vincent; Zakharova, Olga D.; Vasyutina, Elena L.; Yurchenko, Ekaterina; Bayandin, Roman; Litvak, Simon; Tarrago-Litvak, Laura; Nevinsky, Georgy A.
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 11 p. 989 - 1000
参考文献
Takeda Chemical Industries, Inc.
Patent: US6407116 B1, 2002 ;
反应条件
water 24 h; Ambient temperature;
参考文献
Menezes, Royce; Smith, Michael B.
Synthetic Communications, 1988 , vol. 18, # 4 p. 1625 - 1636
反应条件
1: 81 percent / 24 h / Heating 2: 78 percent / HCl / diethyl ether / 0.17 h 3: 90 percent / H2O / 24 h / Ambient temperature View Scheme
参考文献
Menezes, Royce; Smith, Michael B.
Synthetic Communications, 1988 , vol. 18, # 4 p. 1625 - 1636
反应条件
1: 78 percent / HCl / diethyl ether / 0.17 h 2: 90 percent / H2O / 24 h / Ambient temperature View Scheme
参考文献
Menezes, Royce; Smith, Michael B.
Synthetic Communications, 1988 , vol. 18, # 4 p. 1625 - 1636
反应条件
in toluene T=60 - 110°C; 2 h;
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
triethylamine in tetrahydrofuran; aqueous THF
参考文献
Beecham Group Limited
Patent: US4200635 A1, 1980 ;
反应条件
1: 72.94 percent / toluene / 2 h / 60 - 110 °C
2: 90.9 percent / pyridine / 3 h / 90 °C
3: 48.8 percent / 1.) pyridine, triethylamine / 1.) 5 deg C, 30 min.; 2.) 20 deg C, 30 min.
4: 51.1 percent / conc. HCl / methanol / 14 h / 30 °C
5: 43.7 percent / NaBH4 / methanol / 1.5 h / 5 - 10 °C
View Scheme
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
1: 2.20 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
2: 80 percent / hydrazine hydrate / ethanol / 24 h / Heating
View Scheme
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Elsinghorst, Paul W.; Gonzalez Tanarro, Camino M.; Guetschow, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7540 - 7544
